Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
Department of Obstetrics and Gynecology, Graduate School of Medicine, Akita University, Japan.
Intern Med. 2022 Oct 15;61(20):3137-3140. doi: 10.2169/internalmedicine.8886-21. Epub 2022 Mar 12.
A 28-year-old woman exhibited a spiking fever, arthritis, and liver disfunction when she was 22 weeks pregnant. She was diagnosed with adult-onset Still's disease (AOSD). As her condition was resistant to corticosteroid therapy, tocilizumab (TCZ) was selected. The TCZ treatment was effective, and she delivered a healthy child while receiving TCZ treatment. Cases in which AOSD first arises during pregnancy are rare, and there have been no reports of TCZ treatment for AOSD being initiated during pregnancy. Although the safety of TCZ treatment during pregnancy has not been established, it may be effective against severe AOSD that develops during pregnancy.
一位 28 岁女性在怀孕 22 周时出现高热、关节炎和肝功能异常。她被诊断为成人Still 病（AOSD）。由于她的病情对皮质类固醇治疗无反应，因此选择了托珠单抗（TCZ）。TCZ 治疗有效，她在接受 TCZ 治疗的同时生下了一个健康的孩子。妊娠期间首次出现 AOSD 的病例很少，也没有报道称在妊娠期间开始 TCZ 治疗 AOSD。虽然尚未确定 TCZ 治疗在怀孕期间的安全性，但它可能对妊娠期间发生的严重 AOSD 有效。
