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在严格血压控制下使用托珠单抗治疗成年发病的幼年特发性关节炎、淀粉样变性 A 淀粉样变性和慢性肾脏病患者取得成功妊娠结局。

Successful Pregnancy Outcome in a Patient with Juvenile Idiopathic Arthritis in Adulthood, Amyloid A Amyloidosis, and Chronic Kidney Disease Using Tocilizumab with Strict Blood Pressure Control.

机构信息

Division of Rheumatology and Allergy, Osaka General Medical Center, Japan.

Department of Obstetrics/Gynecology, Osaka General Medical Center, Japan.

出版信息

Intern Med. 2024 May 1;63(9):1311-1316. doi: 10.2169/internalmedicine.1951-23. Epub 2023 Sep 29.

Abstract

Pregnancies with chronic kidney disease (CKD) and high disease activity in rheumatic diseases are high-risk events with adverse outcomes for both the mother and fetus. We herein report a 35-year-old woman with juvenile idiopathic arthritis (JIA), amyloid A (AA) amyloidosis related to JIA, and CKD stage G4A2 who wished to have children. She achieved a successful pregnancy, even in the presence of these multiple risk factors, using tocilizumab to control the disease activity of JIA and AA amyloidosis, along with antihypertensive drugs to control her blood pressure before and during pregnancy.

摘要

患有慢性肾脏病 (CKD) 和风湿性疾病高疾病活动度的妊娠是高危事件,对母亲和胎儿都有不良结局。本文报告了一例 35 岁患有幼年特发性关节炎 (JIA)、与 JIA 相关的淀粉样 A (AA) 淀粉样变性和 CKD G4A2 期的女性,她希望生育孩子。尽管存在这些多种危险因素,她仍通过使用托珠单抗控制 JIA 和 AA 淀粉样变性的疾病活动度,以及在妊娠前后使用降压药物控制血压,成功妊娠。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c734/11116017/10b3b4f11eae/1349-7235-63-1311-g001.jpg

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