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阿片类药物滥用与围手术期护理:一种新的医学疾病。

Opioid abuse and perioperative care: a new medical disease.

机构信息

Department of Anesthesiology, Section on Regional Anesthesia and Acute Pain Management.

Department of Anesthesiology, Section on Critical Care Medicine, Wake Forest School of Medicine, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina.

出版信息

Curr Opin Anaesthesiol. 2022 Jun 1;35(3):401-408. doi: 10.1097/ACO.0000000000001121. Epub 2022 Mar 11.

Abstract

PURPOSE OF REVIEW

This review article aims to describe the perioperative clinical implications of opioid use or opioid use disorder (OUD) and to provide recommendations related to analgesia, anesthesia, and postoperative care for patients with this 'new medical disease'.

RECENT FINDINGS

Evidence suggest that 1 in 4 surgical patients will be using opioids preoperatively. Management of these patients, or those with OUD, can be challenging given their opioid tolerance, hyperalgesia, decreased pain tolerance, and increased pain sensitivity. Therefore, an individualized plan that considers how to manage OUD treatment medications, the risk of relapse, multimodal analgesia, and postoperative monitoring requirements is highly important. Fortunately, recent publications provide both insight and guidance on these topics. Postoperatively, persistent opioid utilization appears higher in patients currently using opioids and even for those with a prior history. Although numerous other adverse outcomes are also associated with opioid use or abuse, some may be modifiable with cessation.

SUMMARY

A coordinated, evidence-based, multidisciplinary team approach is critical when caring for patients with OUD to ensure safety, provide adequate analgesia, and reduce the risk of relapse. Enhanced postoperative monitoring, multimodal analgesia, and a plan for preoperative opioid management may help to modify the risks of adverse postoperative outcomes.

摘要

目的综述

本文旨在描述围手术期使用阿片类药物或阿片类药物使用障碍(OUD)的临床意义,并就此类“新出现的医学疾病”患者的镇痛、麻醉和术后护理提供相关建议。

最近的发现

有证据表明,每 4 名手术患者中就有 1 名患者术前正在使用阿片类药物。鉴于这些患者的阿片类药物耐受、痛觉过敏、疼痛耐量降低和疼痛敏感性增加,管理这些患者或 OUD 患者具有挑战性。因此,制定个体化计划非常重要,该计划需要考虑如何管理 OUD 治疗药物、复发风险、多模式镇痛以及术后监测要求。幸运的是,最近的出版物为这些主题提供了深入的见解和指导。术后,持续使用阿片类药物的患者(包括目前正在使用阿片类药物的患者和有既往使用史的患者)比例似乎更高。尽管许多其他不良后果也与阿片类药物的使用或滥用有关,但一些后果可能通过停药得到改善。

总结

在治疗 OUD 患者时,需要采取协调的、基于证据的多学科团队方法,以确保安全、提供充分的镇痛并降低复发风险。增强术后监测、多模式镇痛以及术前阿片类药物管理计划,可能有助于降低不良术后结局的风险。

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