Saini Shivani, Jain Akshay K, Agarwal Shail, Yadav Devendra
Department of Skin and VD, Dr. SN Medical College, Jodhpur, Rajasthan, India.
Department of Skin and VD, Govt. Medical College, Kota, Rajasthan, India.
Indian J Dermatol. 2021 Nov-Dec;66(6):705. doi: 10.4103/ijd.ijd_326_21.
As generalized pruritus can be a symptom of a systemic disease, iron deficiency may be the underlying internal cause of its symptoms. Because data on the relationship between iron deficiency and generalized chronic pruritus are limited, more research is needed to ensure proper diagnosis and management.
To evaluate the prevalence of iron deficiency in patients with generalized chronic pruritus in the southeast region of Rajasthan and to assess the correlation of serum ferritin with iron deficiency variables.
An observational, analytical study was conducted among a total of 200 patients complaining of itching all across the body without any skin lesions for more than 6 weeks and enrolled in the outdoor and indoor Dermatology, Venereology, and Leprology departments of the Government Medical College, Kota. The duration of the study experiment was 1 year from June 2018 to May 2019.
Females (108; 54%) were more than males (92; 46%) with a ratio of 1.17:1. The mean age of the patients was 37.35 ± 13.56. S. ferritin was found to be below 15 g/L in 58 (29%) patients. Significant correlation was found between S. ferritin and hemoglobin, MCV, MCH, and MCHC, and the value was <0.05. Maximum number of patients (70; 35%) achieved visual analog scale (VAS) scores between 4 and 9, followed by 50 (25%) patients obtaining scores >9. Similarly, a correlation was found between the VAS score and hemoglobin, MCV, MCH, and MCHC and a statistically significant value was obtained.
The sample size was small in the study. The overall levels of iron and serum transferrin were not checked, keeping patients' compliance in mind.
Although statistically significant results were found, limitations were also present in our study; so, further studies for proper diagnosis and management should be conducted in greater depth.
由于全身性瘙痒可能是一种全身性疾病的症状，缺铁可能是其症状的潜在内在原因。由于关于缺铁与全身性慢性瘙痒之间关系的数据有限，需要更多研究以确保正确的诊断和管理。
评估拉贾斯坦邦东南部全身性慢性瘙痒患者中铁缺乏的患病率，并评估血清铁蛋白与缺铁变量之间的相关性。
对政府医学院科塔分校皮肤科、性病科和麻风病科门诊及住院的200例全身瘙痒超过6周且无任何皮肤病变的患者进行了一项观察性分析研究。研究实验为期1年，从2018年6月至2019年5月。
女性（108例；54%）多于男性（92例；46%），比例为1.17:1。患者的平均年龄为37.35±13.56岁。58例（29%）患者的血清铁蛋白低于15μg/L。血清铁蛋白与血红蛋白、平均红细胞体积、平均红细胞血红蛋白含量和平均红细胞血红蛋白浓度之间存在显著相关性，P值<0.05。最大数量的患者（70例；35%）视觉模拟量表（VAS）评分在4至9分之间，其次是50例（25%）患者评分>9分。同样，VAS评分与血红蛋白、平均红细胞体积、平均红细胞血红蛋白含量和平均红细胞血红蛋白浓度之间存在相关性，并获得了具有统计学意义的P值。
本研究样本量较小。考虑到患者依从性，未检查铁和血清转铁蛋白的总体水平。
尽管本研究发现了具有统计学意义的结果，但也存在局限性；因此，应更深入地开展进一步研究以进行正确的诊断和管理。
