Department of Pharmacology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Pharm Biol. 2012 Apr;50(4):443-52. doi: 10.3109/13880209.2011.611145. Epub 2011 Dec 2.
Herbal remedies are used to treat a large variety of diseases, including blood-related disorders. However, a number of herbal preparations have been reported to cause variations in clotting time, this is mainly by disruption of the coagulation cascade.
The compiling of plants investigated for effects on the coagulation cascade.
Information was withdrawn from Google Scholar and the journal databases Scopus and PubMed.
Sixty-five herbal remedies were identified with antiplatelet, anticoagulant, or coagulating ability. Bioactive compounds included polyphenols, taxanes, coumarins, saponins, fucoidans, and polysaccharides.
Although research has been conducted on the effect of herbal remedies on coagulation, most information relies on in vitro assays. Contradictory evidence is present on bleeding risks with herbal uses, though herb-drug interactions pose a threat. As the safety of many herbals has not been proven, nor their effect on blood parameters determined, the use of herbal preparations before undergoing any surgical procedure should discontinued.
草药被用于治疗多种疾病，包括血液相关疾病。然而，许多草药制剂已被报道会导致凝血时间的变化，这主要是通过破坏凝血级联反应。
编译调查对凝血级联反应有影响的植物。
从 Google Scholar 和 Scopus、PubMed 期刊数据库中提取信息。
确定了 65 种具有抗血小板、抗凝或凝血能力的草药。生物活性化合物包括多酚、紫杉烷、香豆素、皂苷、褐藻酸盐和多糖。
尽管已经对草药对凝血的影响进行了研究，但大多数信息依赖于体外检测。关于草药使用的出血风险存在相互矛盾的证据，尽管草药-药物相互作用构成了威胁。由于许多草药的安全性尚未得到证实，也没有确定其对血液参数的影响，因此在进行任何手术前应停止使用草药制剂。
