Abbasian Mahdi, Langlois Annick, Gibon Julien
Biology Department, University of British Columbia Okanagan, Kelowna, BC, Canada.
Front Behav Neurosci. 2022 Feb 24;16:842552. doi: 10.3389/fnbeh.2022.842552. eCollection 2022.
The p75 neurotrophin receptor (p75NTR) is implicated in various biological functions during development and adulthood. Several animal models have been developed to identify the roles of p75NTR and . P75NTR knock-out mice are widely used to study the neurotrophin receptor and its signaling pathways. Similar to other models of p75NTR knock-out (p75NTR KO) or conditional knock-out (p75NTR) mice, p75NTR knock-out mice present severe abnormalities in walking, gait, balance and strength. The present study identifies a sexual dimorphism in the p75NTR knock-out strain regarding balance and coordination. Using Kondziela's inverted grid test, we observed that p75NTR knock-out males performed poorly at the task, whereas p75NTR knock-out females did not exhibit any defects. We also observed that female p75NTR knock-out mice performed significantly better than male p75NTR knock-out mice at the beam balance test. There were no differences in strength, skin innervation, or the number of ulcers on the toes between p75NTR knock-out males and females. The literature regarding the role of p75NTR in behavior is controversial; our results suggest that studies investigating the role of p75NTR using p75NTR knock-out mice should systematically report data from males and females.
p75神经营养因子受体（p75NTR）在发育和成年期的各种生物学功能中都有涉及。已经建立了几种动物模型来确定p75NTR的作用。p75NTR基因敲除小鼠被广泛用于研究神经营养因子受体及其信号通路。与其他p75NTR基因敲除（p75NTR KO）或条件性敲除（p75NTR）小鼠模型类似，p75NTR基因敲除小鼠在行走、步态、平衡和力量方面存在严重异常。本研究确定了p75NTR基因敲除品系在平衡和协调方面存在性别差异。使用孔齐埃拉倒网格试验，我们观察到p75NTR基因敲除雄性小鼠在该任务中表现不佳，而p75NTR基因敲除雌性小鼠没有表现出任何缺陷。我们还观察到，在光束平衡试验中，雌性p75NTR基因敲除小鼠的表现明显优于雄性p75NTR基因敲除小鼠。p75NTR基因敲除的雄性和雌性小鼠在力量、皮肤神经支配或脚趾溃疡数量方面没有差异。关于p75NTR在行为中作用的文献存在争议；我们的结果表明，使用p75NTR基因敲除小鼠研究p75NTR作用的研究应系统地报告来自雄性和雌性的数据。
