Chen Jing, Zheng Yixin, Hu Chen, Jin Xuexiao, Chen Xiaoping, Xiao Ying, Wang Chaochen
Department of Breast Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhejiang University - University of Edinburgh Institute, Zhejiang University, Haining, China.
Front Physiol. 2022 Feb 24;13:839859. doi: 10.3389/fphys.2022.839859. eCollection 2022.
Hair graying is an interesting physiological alteration associated with aging and certain diseases. The occurrence is due to depigmentation of the hair caused by depletion and dysfunction of melanocyte stem cells (MeSCs). However, what causes the depletion and dysfunction of MeSCs remains unclear. MeSCs reside in the hair follicle bulge which provides the appropriate niche for the homeostasis of various stem cells within hair follicle including MeSCs. In addition to local signaling from the cells composed of hair follicle, emerging evidences have shown that nerves, adipocytes and immune cells outside of hair follicle also play important roles in the regulation of MeSCs. Here, we review the recent studies on different cells in the MeSCs microenvironment beyond the hair follicle , discuss their function in regulating hair graying and potentially novel treatments of hair graying.
头发变白是一种与衰老和某些疾病相关的有趣生理变化。其发生是由于黑素细胞干细胞（MeSCs）的耗竭和功能障碍导致头发色素脱失。然而，MeSCs耗竭和功能障碍的原因仍不清楚。MeSCs位于毛囊隆突部，该部位为包括MeSCs在内的毛囊内各种干细胞的稳态提供了适宜的微环境。除了来自毛囊组成细胞的局部信号外，新出现的证据表明，毛囊外的神经、脂肪细胞和免疫细胞在MeSCs的调节中也发挥着重要作用。在此，我们综述了毛囊外MeSCs微环境中不同细胞的最新研究，讨论它们在调节头发变白中的作用以及潜在的头发变白新治疗方法。
