School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.
School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore; Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 Cleantech Loop, CleanTech One, 637141, Singapore.
Ageing Res Rev. 2023 Nov;91:102041. doi: 10.1016/j.arr.2023.102041. Epub 2023 Aug 25.
Aging is a complex natural process that leads to a decline in physiological functions, which is visible in signs such as hair graying, thinning, and loss. Although hair graying is characterized by a loss of pigment in the hair shaft, the underlying mechanism of age-associated hair graying is not fully understood. Hair graying and loss can have a significant impact on an individual's self-esteem and self-confidence, potentially leading to mental health problems such as depression and anxiety. Omics technologies, which have applications beyond clinical medicine, have led to the discovery of candidate hair biomarkers and may provide insight into the complex biology of hair aging and identify targets for effective therapies. This review provides an up-to-date overview of recent omics discoveries, including age-associated alterations of proteins and metabolites in the hair shaft and follicle, and highlights the significance of hair aging and graying biomarker discoveries. The decline in hair follicle stem cell activity with aging decreased the regeneration capacity of hair follicles. Cellular senescence, oxidative damage and altered extracellular matrix of hair follicle constituents characterized hair follicle and hair shaft aging and graying. The review attempts to correlate the impact of endogenous and exogenous factors on hair aging. We close by discussing the main challenges and limitations of the field, defining major open questions and offering an outlook for future research.
衰老是一个复杂的自然过程，导致生理功能下降，这在头发变白、变薄和脱落等迹象中可见一斑。尽管头发变白的特征是头发轴中的色素丧失，但与年龄相关的头发变白的潜在机制尚不完全清楚。头发变白和脱落会对个人的自尊心和自信心产生重大影响，可能导致抑郁和焦虑等心理健康问题。组学技术的应用不仅限于临床医学，已经发现了候选头发生物标志物，并可能深入了解头发衰老的复杂生物学，并确定有效的治疗靶点。本综述提供了最近组学发现的最新概述，包括头发轴和毛囊中与年龄相关的蛋白质和代谢物的改变，并强调了头发衰老和变白生物标志物发现的重要性。随着年龄的增长，毛囊干细胞活性的下降降低了毛囊的再生能力。细胞衰老、氧化损伤和毛囊成分细胞外基质的改变是毛囊和头发轴衰老和变白的特征。该综述试图将内源性和外源性因素对头发衰老的影响联系起来。最后，我们讨论了该领域的主要挑战和局限性，确定了主要的开放性问题，并对未来的研究进行了展望。
