[Immunological aspects of nucleolar activation. III. Changes in nucleolar activation after application of S III pneumococcal polysaccharide in vivo].

Intraperitoneal application of 0.7 microgram S III pneumococcal polysaccharide led to a significant increase in the values of nucleolar activation in small, medium, and large lymphocytes, plasmoblasts, and plasmatic cells in a white mouse. Macrophages did not respond to the application of S III by an increase in nucleolar activation. The study tested the possibility of using the observation of the functional morphology of the nucleous for observing the changes in the activation of B-cells after administration of nonspecific mitogen and a thymus-independent antigen.