[Immunopathological aspects of nucleolar activation. 1. Changes of nucleolar activation during the course of primary immune response].

During the primary immune response induced by the administration of sheep erythrocytes in mice, nucleolar activation was observed in macrophages, lymphocytes as well as in plasmacytes. The first maximum (4.6%) was observed on day 3 in macrophagic cells. Maximal activation of plasmoblasts (6.6%) and plasmacytes (5.9%) was observed on day the lymphoid series the first maximum in the occurrence of cells showing specific immunological activatin was as follows: large lymphocytes on day (6.5%), medium-sized lymphocytes on day 7 (6.6%) and, ultimately, small lymphocytes (6.3%) on day 8. The study verified the possibility of using nucleolar staining for estimating its functional morphology and thus following the changes of specific immunological activation during the primary immunological response.