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[疫苗免疫原性的探索]

[Exploration of vaccine immunogenicity].

作者信息

Denis Jessica, Mura Marie, Trignol Aurélie, Tournier Jean-Nicolas

机构信息

Unité immunopathologie, Institut de recherche biomédicale des armées, 1 place du général-Valérie-André, 91220 Brétigny-sur-Orge, France.

Département microbiologie et maladies infectieuses, Institut de recherche biomédicale des armées, 1 place du général-Valérie-André, 91220 Brétigny-sur-Orge, France.

出版信息

Rev Francoph Lab. 2022 Mar;2022(540):40-52. doi: 10.1016/S1773-035X(22)00098-3. Epub 2022 Mar 4.

DOI:10.1016/S1773-035X(22)00098-3
PMID:35284007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8896448/
Abstract

The development of new vaccines has traditionally been a long-term job, although recent experience with the emergence of Covid-19 has caused development and production delays to skyrocket. The fact remains that the development of vaccines in the preclinical phases and in phases 1 and 2 of clinical development is based on the study of the specific immune response of the adaptive immune system.

摘要

传统上，新型疫苗的研发是一项长期工作，尽管近期新冠疫情的出现导致研发和生产延迟大幅增加。但事实仍然是，临床前阶段以及临床研发1期和2期的疫苗研发是基于对适应性免疫系统特异性免疫反应的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/ba60f6403ec5/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/f9d246edca2c/fx1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/3b833cde72d6/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/19219b93f36c/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/9ae65e7af7fc/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/6d4d1e30fdb2/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/3a4f694e073a/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/be6d35c4b783/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/ba60f6403ec5/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/f9d246edca2c/fx1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/3b833cde72d6/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/19219b93f36c/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/9ae65e7af7fc/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/6d4d1e30fdb2/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/3a4f694e073a/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/be6d35c4b783/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/8896448/ba60f6403ec5/gr7_lrg.jpg

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本文引用的文献

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Immunoprofiling Identifies Functional B and T Cell Subsets Induced by an Attenuated Whole Parasite Malaria Vaccine as Correlates of Sterile Immunity.免疫谱分析鉴定减毒全寄生虫疟疾疫苗诱导的功能性B细胞和T细胞亚群为无菌免疫的相关因素。
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通过灵敏的竞争性酶联免疫吸附测定法检测和定量严重急性呼吸综合征冠状病毒2受体结合域的中和作用
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Intrinsic ADE: The Dark Side of Antibody Dependent Enhancement During Dengue Infection.固有 ADE：登革热感染期间抗体依赖增强的阴暗面。
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