Louwrens Anisca, Fourie Carla M T, Roux Shani Botha-Le, Breet Yolandi
Hypertension in Africa Research Team (HART), School for Physiology, Nutrition and Consumer Science, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
MRC Research Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
South Afr J HIV Med. 2022 Feb 24;23(1):1335. doi: 10.4102/sajhivmed.23i1.1335. eCollection 2022.
As the life expectancy of people living with the HIV increases because of antiretroviral treatment (ART), their risk for vascular co-morbidities and early vascular ageing (EVA) also increases.
We aimed to investigate whether HIV infection relates to vascular structure and function in black South African adults and whether this relationship is age dependent.
This cross-sectional study carried out in urban and rural areas of North West province, South Africa, included 572 age- and sex-matched people living with HIV (PLWH) and without HIV. Participants from the EndoAfrica study and PURE study were stratified according to tertiles of age. Measures of vascular structure (carotid intima-media thickness) and function (carotid-femoral pulse wave velocity, central systolic blood pressure, central pulse pressure and pulse pressure amplification) were determined.
Blood pressure measures were lower in PLWH compared with their controls (all ≤ 0.001), especially in the younger and middle-aged groups (all ≤ 0.031), whilst vascular measures did not differ (all ≥ 0.611). In multivariate linear regression analyses, vascular measures were not associated with a HIV- positive status in either the total or any of the age groups.
Black South Africans living with HIV have a less adverse blood pressure profile than their counterparts without HIV. The HIV-positive status was not associated with measures of vascular structure or function in any age group. The results suggest that HIV does not contribute to EVA in this population; however, further longitudinal investigation is warranted.
由于抗逆转录病毒治疗（ART），感染人类免疫缺陷病毒（HIV）的人的预期寿命增加，他们患血管合并症和早期血管老化（EVA）的风险也增加。
我们旨在调查HIV感染是否与南非黑人成年人的血管结构和功能有关，以及这种关系是否与年龄有关。
这项横断面研究在南非西北省的城乡地区进行，纳入了572名年龄和性别匹配的HIV感染者（PLWH）和未感染HIV的人。来自EndoAfrica研究和PURE研究的参与者按年龄三分位数分层。测定血管结构（颈动脉内膜中层厚度）和功能（颈股脉搏波速度、中心收缩压、中心脉压和脉压放大）指标。
与对照组相比，PLWH的血压测量值较低（均≤0.001），尤其是在年轻和中年组（均≤0.031），而血管测量值无差异（均≥0.611）。在多变量线性回归分析中，无论是总体还是任何年龄组，血管测量值均与HIV阳性状态无关。
感染HIV的南非黑人的血压状况比未感染HIV的人更有利。在任何年龄组中，HIV阳性状态均与血管结构或功能指标无关。结果表明，在该人群中HIV不会导致EVA；然而，有必要进行进一步的纵向研究。
