Horwitt M K
J Nutr. 1986 Jul;116(7):1371-7. doi: 10.1093/jn/116.7.1371.
Investigations that have influenced the promotion of vitamin E supplementation are reviewed. The various forms of vitamin E found in foods and the composition of synthetic vitamin E in common use are described with note of a frequent error of identification made in reports of studies on vitamin E. Recent communications on the use of antioxidants to delay carcinogenesis in animals and in humans are discussed. The publicity given the reports of cancer prevention by antioxidants will probably increase self-supplementations. It is therefore necessary to understand the pharmacological limits of such supplementation with vitamin E. Daily supplementation of adults with about 200 mg of d-alpha-tocopherol equivalents per day has not been proven to be harmful, but the effects of ingestion of more than 800 mg a day have not been studied sufficiently. Special precautions should be taken in administering emulsified vitamin E preparations intravenously to premature infants.
本文回顾了影响维生素E补充剂推广的相关研究。介绍了食物中发现的各种维生素E形式以及常用合成维生素E的成分，并指出维生素E研究报告中常见的识别错误。讨论了近期关于使用抗氧化剂延缓动物和人类癌症发生的相关报道。抗氧化剂预防癌症的报道宣传可能会增加自我补充的情况。因此，有必要了解这种维生素E补充的药理学限度。成人每天补充约200毫克d-α-生育酚当量尚未被证明有害，但每天摄入超过800毫克的影响尚未得到充分研究。给早产儿静脉注射乳化维生素E制剂时应特别谨慎。
