Pierce T
J Occup Med. 1986 Aug;28(8):589-92. doi: 10.1097/00043764-198608000-00013.
Immunoassay techniques may represent useful screening tools to assist analysts interested in the presence and amounts of organic toxicants in biological fluids. The widespread application of immunoassay methods in medicinal and forensic (drugs of abuse) chemistry has resulted in such screening methodologies. Four methodologies of potential benefit are considered: the free radical assay technique, the enzyme-mediated immunoassay technique, radioimmunoassay, and hemagglutination. Each of these immunoassays is based on the competitive displacement of the labeled drug (or toxicant) from the antibody complex by the unlabeled drug-toxicant in the sample.
免疫分析技术可能是有用的筛查工具，可帮助对生物体液中有机毒物的存在和含量感兴趣的分析人员。免疫分析方法在药物化学和法医（滥用药物）化学中的广泛应用催生了此类筛查方法。本文考虑了四种可能有益的方法：自由基检测技术、酶介导免疫分析技术、放射免疫分析和血凝反应。这些免疫分析方法均基于样品中未标记的药物毒物竞争性取代抗体复合物中标记药物（或毒物）的原理。
