Han Shan-Shan, Dai Yan-Lin, Ding Ying, Zhang Xia, Sun Li-Hui, Gao Min
Department of Pediatrics, First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China School of Pediatrics, Henan University of Chinese Medicine Zhengzhou 450000, China Henan Children's Hospital of Integrated Traditional Chinese and Western Medicine Zhengzhou 450000, China.
School of Pediatrics, Henan University of Chinese Medicine Zhengzhou 450000, China.
Zhongguo Zhong Yao Za Zhi. 2022 Feb;47(4):1085-1094. doi: 10.19540/j.cnki.cjcmm.20211108.501.
This study systematically searched CNKI and Web of Science(WoS) for the research papers on the toxicity of Tripterygium wilfordii included from database inception to August 31, 2021, and visually displayed the authors, research institutions, keywords, and other contents using bibliometrics and CiteSpace 5.8.3. Furthermore, the current situation and research progress on T. wilfordii safety were also analyzed based on information extraction to find the research hotspot, evolution path, and development trend, and to provide references for future research. A total of 1 876 Chinese papers and 243 English papers were included in the study. The analysis of authors showed that WANG Qi and ZHANG Luyong had the most publications in Chinese and English papers, respectively. According to the analysis of research institutions, National Institutes for Food and Drug Control and China Pharmaceutical University possessed the largest number of Chinese and English papers, respectively, but there was less cooperation between them. The analysis of keywords in Chinese and English papers showed that the research contents of the safety of T. wilfordii mainly focused on clinical monitoring, mechanism, dosage form improvement, quality standard, component analysis, monomer research, efficiency and toxicity reduction, etc. Metabonomics, tripterine, and the underlying mechanism of toxicity were the research hotspots in the future. At present, the research on the toxicity of T. wilfordii is still under development. It is necessary to highlight the in-depth research and strengthen the inter-group and inter-region cooperation of authors or institutions to provide references for the research on the toxicity of T. wilfordii.
本研究系统检索了中国知网（CNKI）和科学网（Web of Science，WoS），查找自建库至2021年8月31日收录的关于雷公藤毒性的研究论文，并运用文献计量学和CiteSpace 5.8.3直观展示作者、研究机构、关键词等内容。此外，还基于信息提取分析雷公藤安全性的研究现状和进展，以找出研究热点、演变路径和发展趋势，为未来研究提供参考。本研究共纳入1876篇中文论文和243篇英文论文。作者分析表明，王琦和张陆勇分别在中文和英文论文中发表量最多。根据研究机构分析，中国食品药品检定研究院和中国药科大学分别拥有最多的中文和英文论文，但二者之间合作较少。中英文论文关键词分析表明，雷公藤安全性的研究内容主要集中在临床监测、作用机制、剂型改进、质量标准、成分分析、单体研究、减毒增效等方面。代谢组学、雷公藤红素及毒性作用机制是未来的研究热点。目前，雷公藤毒性研究仍在发展中。有必要突出深入研究，加强作者或机构之间的组间和区域间合作，为雷公藤毒性研究提供参考。
