Feng Xue, Fang Sai-Nan, Gao Yu-Xin, Liu Jian-Ping, Chen Wei
Centre for Evidence-Based Chinese Medicine， Beijing University of Chinese Medicine， Beijing 100029， China.
Department of Sociology， Acadia University， Wolfville B4P2R6， Canada.
Zhongguo Zhong Yao Za Zhi. 2018 Feb;43(3):425-439. doi: 10.19540/j.cnki.cjcmm.2018.0010.
The study was aimed to conduct an evidence-based evaluation on the safety of Tripterygium wilfordii(TW) preparations through a method combined bibliometrics research with evidence-based evaluation research， to provide evidence-based safety information of the TW preparations(nephrotoxicity) for the government decision-making and clinical application， and to provides methods and suggestions for evaluating nephrotoxicity of Chinese herbal medicine(CHM) in the future. We searched relevant databases at home and abroad systematically， and six Chinese and English databases including CNKI， SinoMed， VIP， WanFang， PubMed， and Cochrane library were comprehensively searched. All types of research documents about the safety of TW preparations. Literature were screened and extracted based on inclusion and exclusion criteria. The methodology quality of all included studies were assessed by internationally recognized evaluation tools or standards. The incidence rate was analyzed by using R software. Subgroup analysis were conducted according to the type of disease treated， drug delivery way， medication time， and study types.
本研究旨在通过文献计量学研究与循证评价研究相结合的方法，对雷公藤制剂的安全性进行循证评价，为政府决策和临床应用提供雷公藤制剂（肾毒性）的循证安全信息，并为今后评价中药肾毒性提供方法和建议。我们系统检索了国内外相关数据库，全面检索了包括中国知网、中国生物医学文献数据库、维普、万方、PubMed和Cochrane图书馆在内的6个中英文数据库。所有关于雷公藤制剂安全性的研究文献。根据纳入和排除标准对文献进行筛选和提取。采用国际公认的评价工具或标准对所有纳入研究的方法学质量进行评估。使用R软件分析发病率。根据治疗疾病类型、给药方式、用药时间和研究类型进行亚组分析。
