Non-Communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran.
Department of Biostatistics and Epidemiology, School of Public Health, Babol University of Medical Sciences, Babol, I.R.Iran.
Expert Rev Vaccines. 2022 Jun;21(6):843-851. doi: 10.1080/14760584.2022.2053677. Epub 2022 Mar 22.
We performed a systematic review and meta-analysis to evaluate the acceptance of a COVID-19 vaccine among pregnant women and its determinants.
We searched the bibliographic databases (Scopus, Medline, and Web of Science) for the relevant studies from 1 January 2020 to 11 July 2021. We pooled the prevalence of vaccine acceptance among pregnant women using a random-effects model and conducted subgroup analyses to explore its determinants. The result was expressed as a pooled prevalence percentage and adjusted odds ratio (aOR) with 95% CIs.
We found ten studies that were suitable, with 16, 696 participants from 32 countries. COVID-19 vaccination acceptability in pregnant women was 54 percent globally (95% CI: 45, 62; I2= 99.05). There was no association between sociodemographic factors including age >35 years (aOR: 1.17, 95%CI: 0.95, 1.43), high education (aOR: 1.03, 95%CI: 0.79, 1.35), income levels (aOR: 1.18, 95%CI: 0.80, 1.75), knowledge scores (aOR: 2.55, 95% CI: 0.78, 8.34) and COVID-19 vaccine acceptance.
About half of pregnant women accepted the COVID-19 vaccine. We did not find any association between sociodemographic factors and COVID-19 vaccine acceptance. However, these findings should be considered with caution due to small number of studies and the substantial heterogeneity between them.
我们进行了系统评价和荟萃分析，以评估孕妇对 COVID-19 疫苗的接受程度及其决定因素。
我们从 2020 年 1 月 1 日至 2021 年 7 月 11 日在 Scopus、Medline 和 Web of Science 等文献数据库中检索相关研究。我们使用随机效应模型汇总孕妇疫苗接种接受率，并进行亚组分析以探讨其决定因素。结果以汇总的接受率百分比和调整后的优势比（aOR）表示，95%置信区间（CI）。
我们发现了十项适合的研究，涉及来自 32 个国家的 16696 名参与者。全球孕妇对 COVID-19 疫苗的接受率为 54%（95%CI：45,62；I2=99.05）。年龄>35 岁（aOR：1.17，95%CI：0.95,1.43）、高教育程度（aOR：1.03，95%CI：0.79,1.35）、收入水平（aOR：1.18，95%CI：0.80,1.75）、知识得分（aOR：2.55，95%CI：0.78,8.34）等社会人口因素与 COVID-19 疫苗接种之间均无关联。
约一半的孕妇接受了 COVID-19 疫苗。我们没有发现社会人口因素与 COVID-19 疫苗接种接受率之间存在任何关联。然而，由于研究数量较少且存在很大的异质性，这些发现应谨慎考虑。
