Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
BMJ Open. 2022 Aug 18;12(8):e061477. doi: 10.1136/bmjopen-2022-061477.
The aim of this study was to perform a systematic review and meta-analysis to estimate the vaccines' acceptance level and to find the factors influencing pregnant women's vaccination decisions, with the goal of assisting in the development of interventions and promoting more research in this area.
Systematic review and meta-analysis.
MEDLINE, Embase, CINAHL and PubMed.
Studies providing any kind of quantitative assessment of overall COVID-19 vaccination acceptance among pregnant women in any country or region across the globe.
The pooled prevalence of COVID-19 vaccine acceptance among pregnant women was calculated using the random-effects model. Subgroup (sensitivity) analysis was performed to determine the overall COVID-19 vaccine acceptance level to understand the sources of substantial heterogeneity.
Out of the 375 studies identified, 17 studies from four continents assessing 25 147 participants (pregnant women) were included in this study. Among the participants, only 49% (95% CI 42% to 56%, p<0.001) had COVID-19 vaccine acceptance. High-income countries (47%; 95% CI 38% to 55%, p<0.001), participants with fewer than 12 years of education (38%; 95% CI 19% to 58%, p<0.001) and multiparous women (48%; 95% CI 31% to 66%, p<0.001) had lower COVID-19 vaccine acceptance. Overall heterogeneity was high (I ≥98%), and publication bias was present (p<0.001). A very weak positive correlation between COVID-19 knowledge and COVID-19 vaccine acceptance was observed (r=0.164; 95% CI -0.946 to 0.972; p=0.8359).
Overall, COVID-19 vaccine acceptance among pregnant women was low across the studies and considerably low among some specific subgroups of participants. These research findings have implications for the development of effective interventions that could increase the COVID-19 vaccine acceptance level among pregnant women to attain herd immunity.
CRD42021277754.
本研究旨在进行系统评价和荟萃分析，以评估疫苗的接受程度，并找出影响孕妇接种决策的因素，旨在为干预措施的制定提供帮助，并促进该领域的更多研究。
系统评价和荟萃分析。
MEDLINE、Embase、CINAHL 和 PubMed。
提供全球任何国家或地区孕妇对 COVID-19 疫苗整体接受程度的任何类型定量评估的研究。
采用随机效应模型计算孕妇对 COVID-19 疫苗接受的总体流行率。进行亚组（敏感性）分析，以确定总体 COVID-19 疫苗接受水平，以了解存在大量异质性的原因。
在 375 项研究中，有 17 项来自四大洲的研究纳入了 25147 名参与者（孕妇）。在这些参与者中，只有 49%（95%置信区间 42%至 56%，p<0.001）有 COVID-19 疫苗接种意愿。高收入国家（47%；95%置信区间 38%至 55%，p<0.001）、受教育程度低于 12 年的参与者（38%；95%置信区间 19%至 58%，p<0.001）和多胎孕妇（48%；95%置信区间 31%至 66%，p<0.001）的 COVID-19 疫苗接种意愿较低。总体异质性很高（I≥98%），且存在发表偏倚（p<0.001）。观察到 COVID-19 知识与 COVID-19 疫苗接种意愿之间存在微弱的正相关（r=0.164；95%置信区间-0.946 至 0.972；p=0.8359）。
总体而言，研究中的孕妇对 COVID-19 疫苗的总体接受程度较低，而在某些特定参与者亚组中接受程度更低。这些研究结果对制定有效的干预措施具有启示意义，这些措施可以提高孕妇对 COVID-19 疫苗的接受程度，以实现群体免疫。
PROSPERO 注册号：CRD42021277754。
