非透析慢性肾脏病患者血尿素氮水平与耳蜗外毛细胞功能的相关性

Correlation between blood urea nitrogen level and cochlear outer hair cell function in non-dialysis chronic kidney disease patients.

作者信息

Purnami Nyilo, Roosmilasari Alfarika, Artono Artono, Mardiana Nunuk

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Academic Medical Center, Surabaya.

2Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Academic Medical Center, Surabaya.

出版信息

J Public Health Res. 2022 Mar 14;11(2):2533. doi: 10.4081/jphr.2022.2533.

DOI:10.4081/jphr.2022.2533

PMID:35285593

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8973202/

Abstract

BACKGROUND

Hearing loss due to impaired cochlear function, which results from increased blood urea nitrogen (BUN) level, is one of the important clinical problems in chronic kidney disease (CKD) patients with uremia. This study aims to determine correlation between blood urea nitrogen (BUN) levels and cochlear Outer Hair Cell (OHC) dysfunction in non-dialysis stage 3-5 CKD patients so that the BUN levels may also be used to determine the presence of cochlear OHC dysfunction.

DESIGN AND METHODS

An observational analytic study with a cross sectional design and consecutive sampling. This study was conducted from November 2019 to February 2020 at the Department of Internal Medicine, Soetomo Hospital, Surabaya, Indonesia, and Otorhinolaryngology-Head and Neck Surgery Department, Soetomo Hospital, Surabaya, Indonesia. Non-dialysis CKD patients who met the inclusion and exclusion criteria were subjected to a Distortion Product Otoacoustic Emissions (DPOAE) test to assess cochlear OHC function at the Otorhinolaryngology-Head and Neck Surgery, Soetomo Hospital, Surabaya.

RESULTS

Female patients were in larger number than male patients in a ratio of 1 : 2. Most of the patients were between 51-60 years of age. DPOAE distribution was referred in 25 patients (83.3%) and pass in 5 patients (16.7%). The highest pass was at 2000 Hz in 24 patients (80.0%), while the refer results were mostly at 12,000 Hz in 29 patients (96.7%). The highest average signal to noise ratio (SNR) was at 2000 Hz and 4000 Hz (12.77 dB and 11.13 dB), while the lowest at 11,000 Hz and 12,000 Hz (1.60 dB and 1.03 dB). Pearson's correlation test on DPOAE results did not show a significant correlation (P >0.05) between BUN levels and impaired cochlear OHC function.

CONCLUSIONS

There was no correlation between increased blood urea nitrogen levels and cochlear outer hair cell function disorders in non-dialysis patients with CKD stage 3-5.

摘要

背景

由于血尿素氮（BUN）水平升高导致耳蜗功能受损引起的听力损失，是慢性肾脏病（CKD）尿毒症患者的重要临床问题之一。本研究旨在确定非透析3 - 5期CKD患者血尿素氮（BUN）水平与耳蜗外毛细胞（OHC）功能障碍之间的相关性，以便BUN水平也可用于确定耳蜗OHC功能障碍的存在。

设计与方法

一项采用横断面设计和连续抽样的观察性分析研究。本研究于2019年11月至2020年2月在印度尼西亚泗水苏托莫医院内科和印度尼西亚泗水苏托莫医院耳鼻咽喉 - 头颈外科进行。符合纳入和排除标准的非透析CKD患者在印度尼西亚泗水苏托莫医院耳鼻咽喉 - 头颈外科接受畸变产物耳声发射（DPOAE）测试，以评估耳蜗OHC功能。

结果

女性患者数量多于男性患者，比例为1 : 2。大多数患者年龄在51 - 60岁之间。25例患者（83.3%）DPOAE结果为引出，5例患者（16.7%）通过。24例患者（80.0%）在2000 Hz时通过率最高，而29例患者（96.7%）引出结果大多在12000 Hz。最高平均信噪比（SNR）在2000 Hz和4000 Hz（分别为12.77 dB和11.13 dB），而最低在11000 Hz和12000 Hz（分别为1.60 dB和1.03 dB）。对DPOAE结果进行Pearson相关性检验，结果显示BUN水平与耳蜗OHC功能受损之间无显著相关性（P >0.05）。