Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Research Institute of Nephrology, Zhengzhou University, Zhengzhou, 450052, China.
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, P.R. China.
Sci Rep. 2019 Jul 18;9(1):10408. doi: 10.1038/s41598-019-46857-7.
We conducted a cross-sectional survey including 23869 participants and aimed to measure the prevalences of and risk factors for chronic kidney disease (CKD) and diabetic kidney disease (DKD) in a Chinese rural population. CKD and DKD status was defined according to the combination of estimated glomerular filtration rate (eGFR) and presence of albuminuria Participant completed a questionnaire involving life-style and relevant medical history, and the blood and urinary specimen were taken. The age- and gender- adjusted prevalences of CKD and DKD were calculated and risk factors associated with the presence of CKD and DKD were analyzed by logistic regression. The overall prevalence of CKD was 16.4% (15.9-16.8%) and of DKD was 2.9% (2.7-3.1%). In participants with diabetes, the overall prevalence of CKD was 35.5% (95% CI = 33.7-37.3%). Factors independently associated with renal damage were age, gender, education, personal income, alcohol consumption, overweight, obesity, diabetes, hypertension and dyslipidemia. Our study shows current prevalences of CKD and DKD in Chinese rural residents. Further researches could identify potential factors explaining the observed differences and implement the interventions to relieve the high burden of CKD and DKD in rural population.
我们进行了一项横断面调查，共纳入 23869 名参与者，旨在测量中国农村人群中慢性肾脏病（CKD）和糖尿病肾病（DKD）的患病率和危险因素。CKD 和 DKD 的状态根据估算肾小球滤过率（eGFR）和白蛋白尿的存在来定义。参与者完成了一份涉及生活方式和相关病史的问卷，并采集了血液和尿液标本。通过逻辑回归分析了年龄和性别调整后的 CKD 和 DKD 的患病率以及与 CKD 和 DKD 存在相关的危险因素。CKD 的总体患病率为 16.4%（15.9-16.8%），DKD 的患病率为 2.9%（2.7-3.1%）。在患有糖尿病的参与者中，CKD 的总体患病率为 35.5%（95%CI=33.7-37.3%）。与肾脏损害独立相关的因素是年龄、性别、教育程度、个人收入、饮酒、超重、肥胖、糖尿病、高血压和血脂异常。我们的研究显示了中国农村居民中 CKD 和 DKD 的当前患病率。进一步的研究可以确定解释观察到的差异的潜在因素，并实施干预措施，以减轻农村人群中 CKD 和 DKD 的高负担。
