Interdisciplinary Program in Biohealth-Machinery Convergence Engineering, Kangwon National University.
Interdisciplinary Program in Biohealth-Machinery Convergence Engineering, Kangwon National University;
J Vis Exp. 2022 Feb 25(180). doi: 10.3791/63492.
Aortic valve dysfunction and stroke have recently been reported in transcatheter aortic valve implantation (TAVI) patients. Thrombus in the aortic sinus and neo-sinus due to hemodynamic changes has been suspected. In vitro experiments help investigate the hemodynamic characteristics in the cases where an in vivo assessment proves to be limited. In vitro experiments are also more robust, and the variable parameters are controlled readily. Particle image velocimetry (PIV) is a popular velocimetry method for in vitro studies. It provides a high-resolution velocity field such that even small-scale flow features are observed. The purpose of this study is to show how PIV is used to investigate the flow field in the aortic sinus after TAVI. The in vitro setup of the aortic phantom, TAVI for PIV, and the data acquisition process and post-processing flow analysis are described. The hemodynamic parameters are derived, including the velocity, flow stasis, vortex, vorticity, and particle residence. The results confirm that in vitro experiments and PIV help investigate the hemodynamic features in the aortic sinus.
经导管主动脉瓣植入术（TAVI）患者中最近报道了主动脉瓣功能障碍和中风。怀疑是由于血流动力学变化导致主动脉窦和新窦内血栓形成。体外实验有助于研究体内评估受限的情况下的血流动力学特征。体外实验也更稳健，并且易于控制可变参数。粒子图像测速（PIV）是一种用于体外研究的流行测速方法。它提供了高分辨率的速度场，从而可以观察到甚至小尺度的流动特征。本研究的目的是展示如何使用 PIV 来研究 TAVI 后主动脉窦中的流场。描述了主动脉模型的体外设置、用于 PIV 的 TAVI 以及数据采集过程和后处理流分析。得出了血流动力学参数，包括速度、血流停滞、涡流、涡度和粒子停留时间。结果证实，体外实验和 PIV 有助于研究主动脉窦中的血流动力学特征。
