Meyer Hans-Jonas, Benkert Franz, Bailis Nikolaos, Lerche Marianne, Surov Alexey
Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.
Department of Respiratory Medicine, University Hospital Leipzig, University of Leipzig, Leipzig, Germany.
Br J Radiol. 2022 Jun 1;95(1134):20211267. doi: 10.1259/bjr.20211267. Epub 2022 Mar 18.
Visceral adipose tissue (VAT) has been established as an important parameter of body composition. It can be assessed by imaging modalities like computed tomography (CT). The purpose of the present study was to analyse the prognostic role of VAT derived from thoracic CT in patients with acute pulmonary embolism (PE).
The clinical database of our center was retrospectively screened for patients with acute PE between 2014 and 2017. Overall, 184 patients were included into the analysis. VAT was assessed on axial slices of the thoracic CT at the level of the first lumbar vertebra. Clinical scores, serological parameters, need for intubation, ICU admission and 30 days mortality were assessed.
Using the previously reported threshold of 100 cm² for visceral obesity definition 136 (73.9%), patients were considered as visceral obese. There was a moderate correlation between VAT and BMI ( = 0.56, < 0.0001). There was also a moderate correlation between VAT and body height ( = 0.41, =< 0.0001). Of all investigated clinical scores relating to acute PE, only the GENEVA score correlated weakly with VAT ( = 0.15, = 0.04). There were significant correlations between VAT and creatinine ( = 0.38, < 0.0001) and Glomerular filtration rate ( = -0.21, = 0.005). No associations were identified for VAT and mortality or visceral obesity and mortality.
VAT was not associated with mortality in patients with acute pulmonary embolism.
Visceral obesity is frequent in patients with acute pulmonary embolism but it is not associated with mortality.
内脏脂肪组织（VAT）已被确立为身体组成的一个重要参数。它可通过计算机断层扫描（CT）等成像方式进行评估。本研究的目的是分析胸部CT得出的VAT在急性肺栓塞（PE）患者中的预后作用。
对我们中心2014年至2017年期间急性PE患者的临床数据库进行回顾性筛查。总共184例患者纳入分析。在第一腰椎水平的胸部CT轴位片上评估VAT。评估临床评分、血清学参数、插管需求、入住重症监护病房（ICU）情况及30天死亡率。
采用先前报道的100 cm²内脏肥胖定义阈值，136例（73.9%）患者被视为内脏肥胖。VAT与体重指数（BMI）之间存在中度相关性（r = 0.56，P < 0.0001）。VAT与身高之间也存在中度相关性（r = 0.41，P =< 0.0001）。在所有与急性PE相关的研究临床评分中，只有日内瓦评分与VAT呈弱相关性（r = 0.15，P = 0.04）。VAT与肌酐（r = 0.38，P < 0.0001）和肾小球滤过率（r = -0.21，P = 0.005）之间存在显著相关性。未发现VAT与死亡率或内脏肥胖与死亡率之间存在关联。
急性肺栓塞患者的VAT与死亡率无关。
急性肺栓塞患者中内脏肥胖很常见，但它与死亡率无关。
