Sohag Abdullah Al Mamun, Hossain Md Tahmeed, Rahaman Md Arifur, Rahman Papia, Hasan Mohammad Shahinul, Das Rakhal Chandra, Khan Md Kibria, Sikder Mahmudul Hasan, Alam Mahboob, Uddin Md Jamal, Rahman Md Hasanur, Tahjib-Ul-Arif Md, Islam Tofazzal, Moon Il Soo, Hannan Md Abdul
Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.
Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh.
Phytomedicine. 2022 May;99:154012. doi: 10.1016/j.phymed.2022.154012. Epub 2022 Mar 3.
Plant triterpenoids are major sources of nutraceuticals that provide many health benefits to humans. Lupeol is one of the pentacyclic dietary triterpenoids commonly found in many fruits and vegetables, which is highly investigated for its pharmacological effect and benefit to human health.
This systematic review critically discussed the potential pharmacological benefits of lupeol and its derivatives as evidenced by various cellular and animal model studies. To gain insight into the pharmacological effects of lupeol, the network pharmacological approach is applied. Pharmacokinetics and recent developments in nanotechnology-based approaches to targeted delivery of lupeol along with its safety use are also discussed.
This study is dependent on the systematic and non-exhaustive literature survey for related research articles, papers, and books on the chemistry, pharmacological benefits, pharmacokinetics, and safety of lupeol published between 2011 and 2021. For online materials, the popular academic search engines viz. Google Scholar, PubMed, Science Direct, Scopus, ResearchGate, Springer, as well as official websites were explored with selected keywords.
Lupeol has shown promising benefits in the management of cancer and many other human diseases such as diabetes, obesity, cardiovascular diseases, kidney and liver problems, skin diseases, and neurological disorders. The pharmacological effects of lupeol primarily rely on its capacity to revitalize the cellular antioxidant, anti-inflammatory and anti-apoptotic mechanisms. Network pharmacological approach revealed some prospective molecular targets and pathways and presented some significant information that could help explain the pharmacological effects of lupeol and its derivatives. Despite significant progress in molecular pharmacology, the clinical application of lupeol is limited due to poor bioavailability and insufficient knowledge on its mode of action. Structural modification and nanotechnology-guided targeted delivery of lupeol improve the bioavailability and bioactivity of lupeol.
The pentacyclic triterpene lupeol possesses numerous human health-benefiting properties. This review updates current knowledge and critically discusses the pharmacological effects and potential applications of lupeol and its derivatives in human health and diseases. Future studies are needed to evaluate the efficacies of lupeol and its derivatives in the management and pathobiology of human diseases.
植物三萜类化合物是营养保健品的主要来源，对人类健康有诸多益处。羽扇豆醇是常见于许多水果和蔬菜中的五环膳食三萜类化合物之一，因其药理作用及对人类健康的益处而受到广泛研究。
本系统综述批判性地讨论了羽扇豆醇及其衍生物潜在的药理益处，这些益处已在各种细胞和动物模型研究中得到证实。为深入了解羽扇豆醇的药理作用，应用了网络药理学方法。还讨论了羽扇豆醇的药代动力学以及基于纳米技术的羽扇豆醇靶向递送的最新进展及其安全使用情况。
本研究依赖于对2011年至2021年间发表的有关羽扇豆醇的化学、药理益处、药代动力学和安全性的相关研究文章、论文和书籍进行系统且非详尽的文献调查。对于在线资料，利用了热门学术搜索引擎，即谷歌学术、PubMed、科学Direct、Scopus、ResearchGate、Springer以及官方网站，并使用选定的关键词进行搜索。
羽扇豆醇在癌症及许多其他人类疾病（如糖尿病、肥胖症、心血管疾病、肾脏和肝脏问题、皮肤病和神经紊乱）的治疗中显示出有前景的益处。羽扇豆醇的药理作用主要依赖于其激活细胞抗氧化、抗炎和抗凋亡机制的能力。网络药理学方法揭示了一些潜在的分子靶点和途径，并提供了一些重要信息，有助于解释羽扇豆醇及其衍生物的药理作用。尽管分子药理学取得了重大进展，但由于生物利用度差以及对其作用方式的了解不足，羽扇豆醇的临床应用仍然有限。羽扇豆醇的结构修饰和纳米技术引导的靶向递送提高了羽扇豆醇的生物利用度和生物活性。
五环三萜羽扇豆醇具有众多对人类健康有益的特性。本综述更新了当前知识，并批判性地讨论了羽扇豆醇及其衍生物在人类健康和疾病中的药理作用及潜在应用。未来需要开展研究以评估羽扇豆醇及其衍生物在人类疾病管理和病理生物学中的疗效。
