AlMousa Lujain A, Pandey Pratibha, Lakhanpal Sorabh, Kyada Ashish Kumar, H Malathi, Nayak Priya Priyadarshini, Hussain Arif, Hasan Tarique Noorul, Alagal Reham I, Khan Fahad
Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, Punjab, India.
Front Pharmacol. 2025 May 9;16:1594901. doi: 10.3389/fphar.2025.1594901. eCollection 2025.
Triterpenoids from plants are essential sources of nutraceuticals, which possess numerous positive effects on human health. Lupeol (a pentacyclic dietary triterpenoid) is commonly present in edible fruits, vegetables, and medicinal plants. Numerous investigations on the pharmacological properties of lupeol have been carried out in the past 10 years, and the results have shown that the compound has enormous pharmacological properties, including antioxidant, anti-inflammatory, and anticancer properties. Research has shown that lupeol affects the functioning of numerous molecules, including the cytokines IL-2, NFκB, IL4, IL5, cFLIP, ILβ, and Bcl-2. Our review discusses recent advancements in plant lupeol and its underlying mode of action in combating human carcinoma within the timeframe spanning from 2010 to 2024. Also, we have tried to incorporate recent studies reported till date of the finalization of this review. In order to give researchers the most recent information, highlight the limitations of pertinent research at this time, and highlight both the mechanisms of action of lupeol and recent advances in its formulations that should be strengthened in future studies.
植物中的三萜类化合物是营养保健品的重要来源，对人体健康具有众多积极影响。羽扇豆醇（一种五环膳食三萜类化合物）常见于可食用水果、蔬菜和药用植物中。在过去十年中，人们对羽扇豆醇的药理特性进行了大量研究，结果表明该化合物具有巨大的药理特性，包括抗氧化、抗炎和抗癌特性。研究表明，羽扇豆醇会影响众多分子的功能，包括细胞因子IL-2、NFκB、IL4、IL5、cFLIP、ILβ和Bcl-2。我们的综述讨论了2010年至2024年期间植物羽扇豆醇的最新进展及其在对抗人类癌症方面的潜在作用机制。此外，我们试图纳入截至本综述定稿时报道的最新研究。为了给研究人员提供最新信息，突出目前相关研究的局限性，并强调羽扇豆醇的作用机制以及其制剂的最新进展，这些在未来研究中应得到加强。
