3,3-二(吲哚基)吲哚啉-2-酮的合成、α-葡萄糖苷酶抑制、α-淀粉酶抑制及分子对接研究
Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3,3-di(indolyl)indolin-2-ones.
作者信息
Santoso Mardi, Ong Li Lin, Aijijiyah Nur Pasca, Wati First Ambar, Azminah Azminah, Annuur Rose Malina, Fadlan Arif, Judeh Zaher M A
机构信息
Department of Chemistry, Faculty of Science, Institut Teknologi Sepuluh Nopember, Sukolilo, Surabaya, 60111, Indonesia.
NTU Institute for Health Technologies, Interdisciplinary Graduate School, Nanyang Technological University, Research Techno Plaza, XFrontiers Block, #02-07, 50 Nanyang Drive, 637553, Singapore.
出版信息
Heliyon. 2022 Mar 4;8(3):e09045. doi: 10.1016/j.heliyon.2022.e09045. eCollection 2022 Mar.
The synthesized 3,3-di(indolyl)indolin-2-ones - showed desired higher α-glucosidase inhibitory activities and lower α-amylase inhibitory activities than standard drug acarbose. Particularly, compound showed favorable higher α-glucosidase % inhibition of 67 ± 13 and lower α-amylase % inhibition of 51 ± 4 in comparison to acarbose with % inhibition activities of 19 ± 5 and 90 ± 2, respectively. Docking studies of selected 3,3-di(indolyl)indolin-2-ones revealed key interactions with the active sites of both α-glucosidase and α-amylase, further supporting the observed % inhibitory activities. Furthermore, the binding energies are consistent with the % inhibition values. The results suggest that 3,3-di(indolyl)indolin-2-ones may be developed as suitable Alpha Glucosidase Inhibitors (AGIs) and the lower α-amylase activities should be advantageous to reduce the side effects exhibited by commercial AGIs.
合成的3,3-二（吲哚基）吲哚啉-2-酮——与标准药物阿卡波糖相比，显示出所需的更高的α-葡萄糖苷酶抑制活性和更低的α-淀粉酶抑制活性。特别是，与阿卡波糖相比，化合物显示出良好的更高的α-葡萄糖苷酶抑制率67±13和更低的α-淀粉酶抑制率51±4，阿卡波糖的抑制率分别为19±5和90±2。对选定的3,3-二（吲哚基）吲哚啉-2-酮的对接研究揭示了与α-葡萄糖苷酶和α-淀粉酶活性位点的关键相互作用，进一步支持了观察到的抑制率活性。此外，结合能与抑制率值一致。结果表明，3,3-二（吲哚基）吲哚啉-2-酮可开发为合适的α-葡萄糖苷酶抑制剂（AGIs），较低的α-淀粉酶活性应有利于减少商业AGIs表现出的副作用。
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