多环芳烃暴露与成年人群血清 klotho 水平的关系。
The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population.
机构信息
Department of Pathology, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Department of Pathology, Tri-Service General Hospital Songshan Branch, and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
出版信息
BMC Geriatr. 2022 Mar 14;22(1):198. doi: 10.1186/s12877-022-02924-9.
BACKGROUND
Klotho is an important factor involving aging process. Recently, polycyclic aromatic hydrocarbons (PAHs) exposure was reported to have adverse impact on DNA methylation associated with aging. The aim of the current study was to determine the relationship between serum klotho and PAHs exposure in an adult population.
METHODS
A total of 2597 participants obtained from NHANES 2015-2016 were included in this cross-sectional study. Serum klotho levels were analyzed by enzyme-linked immunosorbent assay (ELISA). PAHs exposure was estimated by urinary sample using liquid chromatography-tandem mass spectrometry. The relationship between serum klotho and exposure to PAHS was analyzed by a multivariable linear regression model.
RESULTS
2-napthol and 3-fluorene were significantly associated with decreased klotho. After fully adjusting pertinent variables, PAH exposure was significantly associated with decreased klotho, particularly in men.
CONCLUSION
In the present study we highlighted the significant association between PAHs exposure and serum klotho levels. The importance of environmental effect on aging process and age-related disorders should be paid more attention and clinical intervention is necessary.
背景
Klotho 是一个涉及衰老过程的重要因素。最近，多环芳烃（PAHs）的暴露被报道对与衰老相关的 DNA 甲基化有不利影响。本研究的目的是确定成人人群血清 Klotho 与 PAHs 暴露之间的关系。
方法
本横断面研究纳入了 2015-2016 年 NHANES 中获得的 2597 名参与者。通过酶联免疫吸附试验（ELISA）分析血清 Klotho 水平。通过液相色谱-串联质谱法（LC-MS/MS）对尿液样本进行 PAHs 暴露评估。通过多变量线性回归模型分析血清 Klotho 与 PAHs 暴露之间的关系。
结果
2-萘酚和 3-芴与 Klotho 降低显著相关。在充分调整相关变量后，PAH 暴露与 Klotho 降低显著相关，尤其是在男性中。
结论
本研究强调了 PAHs 暴露与血清 Klotho 水平之间的显著关联。应更加重视环境对衰老过程和与年龄相关疾病的影响，需要进行临床干预。
Zotero 插件