Section of Women's Mental Health, King's College London, London, UK
South London and Maudsley NHS Foundation Trust, London, UK.
BMJ Open. 2022 Mar 14;12(3):e051498. doi: 10.1136/bmjopen-2021-051498.
To compare, in a population of women with gestational diabetes mellitus (GDM), the time to diagnosis of Type 2 diabetes in those with and without common mental disorder (CMD) (depression and/or anxiety) during pregnancy.
prospective study of the Born in Bradford cohort in Bradford, UK.
909 women diagnosed with GDM between 2007 and 2010, with linkage to their primary care records until 2017. The exposed population were women with an indicator of CMD during pregnancy in primary care records. The unexposed were those without an indicator.
Time to diagnosis of type 2 diabetes as indicated by a diagnosis in primary care records.
time to event analysis using Cox regression was employed. Multiple imputation by chained equations was implemented to handle missing data. Models were adjusted for maternal age, ethnicity, education, preconception CMD and tobacco smoking during pregnancy.
165 women (18%) were diagnosed with type 2 diabetes over a follow-up period of around 10 years. There was no evidence of an effect of antenatal CMD on the development of type 2 diabetes following GDM (adjusted HR 0.95; 95% CI 0.57 to 1.57).
Women with CMD were not at an increased risk of type 2 diabetes following GDM. This is reassuring for women with these co-morbidities but requires replication in other study populations.
在患有妊娠期糖尿病（GDM）的女性人群中，比较患有和不患有常见精神障碍（CMD）（抑郁和/或焦虑）的女性在怀孕期间发展为 2 型糖尿病的时间。
英国布拉德福德的 Born in Bradford 队列的前瞻性研究。
909 名在 2007 年至 2010 年间被诊断为 GDM 的女性，与她们的初级保健记录相关联，直到 2017 年。暴露人群是在初级保健记录中有 CMD 指标的女性。未暴露人群是没有该指标的人群。
通过初级保健记录中的诊断指示的 2 型糖尿病的诊断时间。
使用 Cox 回归进行时间事件分析。采用链式方程进行多重插补处理缺失数据。模型调整了产妇年龄、种族、教育程度、孕前 CMD 和怀孕期间吸烟状况。
在大约 10 年的随访期间，有 165 名女性（18%）被诊断患有 2 型糖尿病。妊娠期 CMD 对 GDM 后 2 型糖尿病的发展没有影响（调整后的 HR 0.95；95%CI 0.57 至 1.57）。
患有 CMD 的女性在 GDM 后没有更高的 2 型糖尿病风险。这对于患有这些合并症的女性来说是令人安心的，但需要在其他研究人群中进行复制。
