Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
BMJ Case Rep. 2022 Mar 14;15(3):e247419. doi: 10.1136/bcr-2021-247419.
Only 4% of newly diagnosed bladder cancer (BC) patients present with metastatic disease. The most common reported sites of metastases are lymph nodes, bones, lung, liver and peritoneum. Mandibular metastasis is very rare. We report a case of muscle-invasive urothelial cancer metastasised to the mandible and with an incidental finding of high-risk prostate cancer (PC). Incidental finding of PC in BC patients may be suggestive of a common aetiology. Treatment for BC and PC can be delivered in parallel, including platinum-based chemotherapy, cystectomy and androgen depletion therapy. Prognosis of metastatic BC is poor, and high-risk PC may affect progression-free survival of BC. Our case highlights importance of considering BC metastasis to the jaw as well as synchronous PC in the management of patients presenting with BC.
仅有 4%的新诊断膀胱癌 (BC) 患者出现转移性疾病。最常见的转移部位是淋巴结、骨骼、肺、肝和腹膜。下颌骨转移非常罕见。我们报告了一例肌肉浸润性尿路上皮癌转移至下颌骨，并意外发现高危前列腺癌 (PC)。BC 患者中偶然发现 PC 可能提示存在共同病因。BC 和 PC 的治疗可以并行进行，包括铂类化疗、膀胱切除术和雄激素剥夺治疗。转移性 BC 的预后较差，高危 PC 可能会影响 BC 的无进展生存期。我们的病例强调了在管理出现 BC 的患者时，需要考虑到 BC 向颌骨转移以及同时存在的 PC 的重要性。
