Instituto Oncoclínicas, São Paulo, SP, Brazil.
Dana farber cancer institute, Boston, MA, 02215, USA.
J Gastrointest Cancer. 2023 Jun;54(2):357-367. doi: 10.1007/s12029-022-00816-0. Epub 2022 Mar 14.
Inflammatory bowel disease (IBD), represented by ulcerative colitis and Crohn's disease, is an idiopathic condition caused by a dysregulated immune response to host intestinal microflora, leading to chronic relapsing intestinal inflammation. Individuals with IBD are more prone to die from several diseases, including cancer.
An extensive search was conducted of PubMed using the following medical subject heading-"inflammatory bowel disease" OR "Crohn's disease" OR "ulcerative colitis" AND "cancer."
In this review article, we discuss the oncogenic mechanisms and genomics of colitis-associated colorectal cancer. Beyond this, we describe the multiple other malignancies that IBD patients are at risk for, discuss caveats in the screening and diagnosis of those cancers, and shed light on pitfalls on the management and treatment of cancer in IBD patients.
Patients, caregivers, and health professionals who deal with IBD must be educated on how to identify warning signs so that cancers can be diagnosed and treated as early as possible.
炎症性肠病（IBD），包括溃疡性结肠炎和克罗恩病，是一种特发性疾病，由宿主肠道微生物群的免疫反应失调引起，导致慢性复发性肠道炎症。IBD 患者更容易死于多种疾病，包括癌症。
使用以下医学主题词在 PubMed 上进行广泛搜索-“炎症性肠病”或“克罗恩病”或“溃疡性结肠炎”和“癌症”。
在这篇综述文章中，我们讨论了结肠炎相关结直肠癌的致癌机制和基因组学。除此之外，我们还描述了 IBD 患者易患的多种其他恶性肿瘤，讨论了筛查和诊断这些癌症的注意事项，并阐明了 IBD 患者癌症管理和治疗的陷阱。
必须对患有 IBD 的患者、护理人员和卫生专业人员进行教育，使其了解如何识别警告信号，以便尽早诊断和治疗癌症。
