人视网膜母细胞瘤Y79细胞系中的胰岛素样免疫反应性

Insulin-like immunoreactivity in human retinoblastoma Y79 cell line.

作者信息

Pansky B, Das A, Budd G C, Reid T W

出版信息

Neurosci Lett. 1986 Jul 24;68(2):187-91. doi: 10.1016/0304-3940(86)90139-4.

Abstract

Cells from the Y79 human retinoblastoma cell line were examined by immunofluorescence immunocytochemistry using an antiserum against insulin. All the cells showed intense staining, indicating the presence of insulin-like immunoreactivity in these cells. Our observations suggest that insulin may play an important role in the metabolism of retinoblastoma cells and that it may be possible to use this cell line as an in vitro model for studies on the action of insulin in the metabolism of human retinal cells.

摘要

使用抗胰岛素抗血清，通过免疫荧光免疫细胞化学方法对Y79人视网膜母细胞瘤细胞系的细胞进行了检测。所有细胞均显示出强烈染色，表明这些细胞中存在胰岛素样免疫反应性。我们的观察结果表明，胰岛素可能在视网膜母细胞瘤细胞的代谢中发挥重要作用，并且有可能将该细胞系用作体外模型，以研究胰岛素在人视网膜细胞代谢中的作用。