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尿路上皮癌胚抗原1评分用于前列腺癌的早期检测和风险预测。

Urothelial carcinoembryonic antigen 1 score for early detection of prostate cancer and risk prediction.

作者信息

Lin Youdong, Liu Guihua, Liu Chun, Xie Hui, Wang Xiaoxian, Huang Yudian, Jin Long, Chen Huidan

机构信息

Department of Clinical Laboratory Medicine, Fujian Provincial Hospital, Fujian Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China.

Department of Children Health Care, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China.

出版信息

Cancer Med. 2022 Aug;11(15):2875-2885. doi: 10.1002/cam4.4629. Epub 2022 Mar 15.

DOI:10.1002/cam4.4629
PMID:35289508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9359874/
Abstract

UCA1 score appears useful in detecting nonhigh-risk (including very low-, low-, or intermediate-risk) prostate cancer. Combination of the PSA level and the UCA1 score may significantly reduce the burden of prostate biopsy.

摘要

UCA1评分在检测非高危（包括极低危、低危或中危）前列腺癌方面似乎很有用。前列腺特异性抗原（PSA）水平和UCA1评分相结合可能会显著减轻前列腺活检的负担。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac3/9359874/6a580d41e569/CAM4-11-2875-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac3/9359874/c9cde6cda2e3/CAM4-11-2875-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac3/9359874/729a0a789bbc/CAM4-11-2875-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac3/9359874/6a580d41e569/CAM4-11-2875-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac3/9359874/c9cde6cda2e3/CAM4-11-2875-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac3/9359874/729a0a789bbc/CAM4-11-2875-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac3/9359874/6a580d41e569/CAM4-11-2875-g003.jpg

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MRI-Targeted or Standard Biopsy in Prostate Cancer Screening.MRI 靶向或标准活检在前列腺癌筛查中的应用。
N Engl J Med. 2021 Sep 2;385(10):908-920. doi: 10.1056/NEJMoa2100852. Epub 2021 Jul 9.
2
Prostate-specific antigen levels of ≤4 and >4 ng/mL and risk of prostate cancer-specific mortality in men with biopsy Gleason score 9 to 10 prostate cancer.前列腺特异性抗原水平≤4 和>4ng/ml 与活检 Gleason 评分 9-10 级前列腺癌患者前列腺癌特异性死亡率的关系。
Cancer. 2021 Jul 1;127(13):2222-2228. doi: 10.1002/cncr.33503. Epub 2021 Jun 8.
3
LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells.
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Mol Carcinog. 2020 Oct;59(10):1174-1187. doi: 10.1002/mc.23247. Epub 2020 Aug 17.
4
lncRNA UCA1 Functions as a ceRNA to Promote Prostate Cancer Progression via Sponging miR143.长链非编码RNA UCA1作为竞争性内源RNA，通过吸附miR143促进前列腺癌进展。
Mol Ther Nucleic Acids. 2020 Mar 6;19:751-758. doi: 10.1016/j.omtn.2019.11.021. Epub 2019 Nov 27.
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LncRNA UCA1 acts as a sponge of miR-204 to up-regulate CXCR4 expression and promote prostate cancer progression.长链非编码 RNA UCA1 通过吸附 miR-204 而上调 CXCR4 的表达，促进前列腺癌的进展。
Biosci Rep. 2019 May 2;39(5). doi: 10.1042/BSR20181465. Print 2019 May 31.
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