Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University, Kunming, PR China.
Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou, PR China.
Nat Prod Res. 2023 Jul-Aug;37(15):2493-2499. doi: 10.1080/14786419.2022.2050911. Epub 2022 Mar 15.
A new oxygenated lanostane-type triterpenoid, 20,24-epoxy-lanosta-7,9(11)-dien-3,15,25,26-tetraol (), together with three known compounds (-) were isolated from the fruiting bodies of . Extensive NMR spectrometry and HRESIMS analysis, as well as NMR and ECD calculations elucidated the structure of the new compound. 27-nor-3-hydroxylanosta-7,9(11),23-trien-25-one () showed superior -glucosidase inhibitory activity with IC value of 122.1 μM to that of positive control acarbose (304.6 μM).
从担子菌的子实体中分离得到一种新的含氧羊毛甾烷型三萜 20,24-环氧-羊毛甾-7,9(11)-二烯-3,15,25,26-四醇 ()，以及三种已知化合物 (-)。通过广泛的 NMR 光谱和 HRESIMS 分析以及 NMR 和 ECD 计算阐明了新化合物的结构。27-降-3-羟基羊毛甾-7,9(11),23-三烯-25-酮 ()对 -葡萄糖苷酶的抑制活性优于阳性对照阿卡波糖 (304.6 μM)，IC 值为 122.1 μM。
