Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China.
Department of Forensic Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China.
J Periodontol. 2022 Nov;93(11):1615-1625. doi: 10.1002/JPER.21-0625. Epub 2022 Apr 9.
To investigate the long-term and spatial patterns of incidence, prevalence, and disability-adjusted life year (DALY) rates of severe periodontitis in Asia from 1990 to 2019, and to estimate the associations between disease burden and socioeconomic development using the Socio-Demographic Index (SDI).
Data were obtained from the global burden of disease study 2019. The average annual percent change (AAPC) was calculated to reflect temporal trends, spatial autocorrelation analysis was conducted to estimate the spatial characteristics, and spatial panel models were used to investigate the association between SDI and severe periodontitis burden.
For Asia as a whole, the crude rates increased by 1.10% per year for incidence, 1.42% per year for prevalence, and 1.41% per year for DALY from 1990 to 2019. The age-standardized incidence, prevalence and DALY rates increased by 0.18%, 0.22%, and 0.23% per year, respectively. Spatially, the hot spots of age-standardized incidence, prevalence and DALY rates were located in Southern Asia, besides, these rates all showed increasing trends in most countries, and the increases were clustered in Southeastern Asia. Further, SDI showed a negative association with incidence (coef = -14.44; 95% CI: -24.63, -4.25) and prevalence (coef = -40.09; -51.81, -28.36), and a positive association with DALY rates (coef = 0.31; 0.23; 0.38).
Severe periodontitis poses a serious public health challenge in Asian countries with increasing temporal trends and substantial spatial inequalities. Effective geographically targeted public health interventions and strategies are needed to address the growing burden associated with severe periodontitis.
本研究旨在调查 1990 年至 2019 年亚洲严重牙周炎的发病率、患病率和伤残调整生命年（DALY）率的长期和空间变化模式，并利用社会人口指数（SDI）评估疾病负担与社会经济发展之间的关联。
本研究数据来源于 2019 年全球疾病负担研究。采用平均年变化百分比（AAPC）来反映时间趋势，进行空间自相关分析以估计空间特征，并使用空间面板模型来研究 SDI 与严重牙周炎负担之间的关联。
总体而言，亚洲地区的发病率、患病率和 DALY 率的粗率分别以每年 1.10%、1.42%和 1.41%的速度增加。年龄标准化的发病率、患病率和 DALY 率分别以每年 0.18%、0.22%和 0.23%的速度增加。在空间上，年龄标准化的发病率、患病率和 DALY 率的热点地区位于南亚，除此之外，这些地区的发病率、患病率和 DALY 率都呈上升趋势，且这种上升趋势在东南亚国家更为明显。进一步研究发现，SDI 与发病率（系数=-14.44；95%CI：-24.63，-4.25）和患病率（系数=-40.09；-51.81，-28.36）呈负相关，与 DALY 率呈正相关（系数=0.31；0.23；0.38）。
严重牙周炎在亚洲国家构成了严重的公共卫生挑战，其时间趋势呈上升趋势，且存在显著的空间不平等。需要采取有效的、有针对性的地理公共卫生干预和策略来应对与严重牙周炎相关的日益增长的负担。
