Zhao Dan, Sun Yangyang, Li Xin, Wang Xiaoxiao, Lu Lijie, Li Chen, Pan Yaping, Wang Songlin
Department of Implant Dentistry, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China.
Department of Periodontics, School of Stomatology, China Medical University, Shenyang 110002, China.
Healthcare (Basel). 2023 Sep 28;11(19):2649. doi: 10.3390/healthcare11192649.
A high detection rate of diabetes among dental visitors has been reported recently. This systematic review aimed to evaluate the association between periodontitis and glycated hemoglobin (HbA1c) levels among non-diabetic individuals.
The EMBASE, MEDLINE, Web of Science, Cochrane Library, PubMed, and Open GREY databases were searched, and observational studies published until 1st June 2023 were identified. A methodological quality assessment was conducted based on the original and modified versions of the Newcastle-Ottawa scale. Cohort, case-control, and cross-sectional studies that performed clinical periodontal examinations and measured HbA1c levels in non-diabetic adults were included. A meta-analysis was conducted to estimate the weighted mean difference (WMD) between individuals with and without periodontitis.
In total, 29 case-control and 5 cross-sectional studies were selected from 2583 potentially eligible articles. Among them, sixteen case-control and three cross-sectional studies with moderate to high quality were selected for the meta-analyses. The HbA1c levels in periodontitis patients were significantly higher than those in individuals with healthy periodontal conditions (WMD = 0.16; < 0.001) among the non-diabetic populations.
This study reveals a significant association between periodontitis and HbA1c levels in non-diabetic populations. Thus, HbA1c screening may be recommended to detect potential hyperglycemia in non-diabetic periodontitis patients.
最近有报道称在看牙的人群中糖尿病检出率很高。本系统评价旨在评估非糖尿病个体中牙周炎与糖化血红蛋白（HbA1c）水平之间的关联。
检索了EMBASE、MEDLINE、Web of Science、Cochrane图书馆、PubMed和Open GREY数据库，并确定了截至2023年6月1日发表的观察性研究。基于纽卡斯尔-渥太华量表的原始版本和修改版本进行了方法学质量评估。纳入了对非糖尿病成年人进行临床牙周检查并测量HbA1c水平的队列研究、病例对照研究和横断面研究。进行荟萃分析以估计有牙周炎和无牙周炎个体之间的加权平均差（WMD）。
从2583篇潜在合格文章中总共筛选出29项病例对照研究和5项横断面研究。其中，16项病例对照研究和3项质量中等至高的横断面研究被选入荟萃分析。在非糖尿病人群中，牙周炎患者的HbA1c水平显著高于牙周健康状况个体（WMD = 0.16；<0.001）。
本研究揭示了非糖尿病人群中牙周炎与HbA1c水平之间存在显著关联。因此，可能建议进行HbA1c筛查以检测非糖尿病牙周炎患者的潜在高血糖情况。
