• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

岛叶亚区的结构和功能生物标志物可预测攻击亚量表的性别差异。

Structural and functional biomarkers of the insula subregions predict sex differences in aggression subscales.

机构信息

College of Computer Science and Technology, Zhejiang University of Technology, Hangzhou, China.

Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University, Hangzhou, China.

出版信息

Hum Brain Mapp. 2022 Jun 15;43(9):2923-2935. doi: 10.1002/hbm.25826. Epub 2022 Mar 15.

DOI:10.1002/hbm.25826
PMID:35289969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9120556/
Abstract

Aggression is a common and complex social behavior that is associated with violence and mental diseases. Although sex differences were observed in aggression, the neural mechanism for the effect of sex on aggression behaviors remains unclear, especially in specific subscales of aggression. In this study, we investigated the effects of sex on aggression subscales, gray matter volume (GMV), and functional connectivity (FC) of each insula subregion as well as the correlation of aggression subscales with GMV and FC. This study found that sex significantly influenced (a) physical aggression, anger, and hostility; (b) the GMV of all insula subregions; and (c) the FC of the dorsal agranular insula (dIa), dorsal dysgranular insula (dId), and ventral dysgranular and granular insula (vId_vIg). Additionally, mediation analysis revealed that the GMV of bilateral dIa mediates the association between sex and physical aggression, and left dId-left medial orbital superior frontal gyrus FC mediates the relationship between sex and anger. These findings revealed the neural mechanism underlying the sex differences in aggression subscales and the important role of the insula in aggression differences between males and females. This finding could potentially explain sexual dimorphism in neuropsychiatric disorders and improve dysregulated aggressive behavior.

摘要

攻击行为是一种常见且复杂的社会行为，与暴力和精神疾病有关。尽管在攻击行为中观察到了性别差异，但性别对攻击行为的神经机制仍不清楚，特别是在攻击行为的特定子量表中。在这项研究中，我们调查了性别的影响对攻击子量表、灰质体积 (GMV) 和每个脑岛亚区的功能连接 (FC) 以及攻击子量表与 GMV 和 FC 的相关性。本研究发现，性别显著影响（a）身体攻击、愤怒和敌意；（b）所有脑岛亚区的 GMV；和（c）背外侧无颗粒脑岛 (dIa)、背外侧颗粒脑岛 (dId) 和腹侧颗粒和颗粒脑岛 (vId_vIg) 的 FC。此外，中介分析表明，双侧 dIa 的 GMV 介导了性别与身体攻击之间的关联，左 dId-左内侧眶额上回 FC 介导了性别与愤怒之间的关系。这些发现揭示了攻击子量表中性别差异的神经机制，以及脑岛在男性和女性之间攻击差异中的重要作用。这一发现可能解释了神经精神障碍中的性别二态性，并改善了失调的攻击行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2244/9120556/9d6377a46c2c/HBM-43-2923-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2244/9120556/c702dd225f1e/HBM-43-2923-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2244/9120556/0ae7c011f2fe/HBM-43-2923-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2244/9120556/83caa37d97c0/HBM-43-2923-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2244/9120556/9d6377a46c2c/HBM-43-2923-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2244/9120556/c702dd225f1e/HBM-43-2923-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2244/9120556/0ae7c011f2fe/HBM-43-2923-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2244/9120556/83caa37d97c0/HBM-43-2923-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2244/9120556/9d6377a46c2c/HBM-43-2923-g002.jpg

相似文献

1
Structural and functional biomarkers of the insula subregions predict sex differences in aggression subscales.岛叶亚区的结构和功能生物标志物可预测攻击亚量表的性别差异。
Hum Brain Mapp. 2022 Jun 15;43(9):2923-2935. doi: 10.1002/hbm.25826. Epub 2022 Mar 15.
2
Sex difference in trait empathy is encoded in the human anterior insula.人类前脑岛编码了特质同理心的性别差异。
Cereb Cortex. 2023 Apr 25;33(9):5055-5065. doi: 10.1093/cercor/bhac398.
3
Neuroanatomical and functional alterations of insula in mild traumatic brain injury patients at the acute stage.轻度创伤性脑损伤患者急性期岛叶的神经解剖和功能改变。
Brain Imaging Behav. 2020 Jun;14(3):907-916. doi: 10.1007/s11682-019-00053-3.
4
Parcellation of the human orbitofrontal cortex based on gray matter volume covariance.基于灰质体积协方差的人类眶额皮质分区
Hum Brain Mapp. 2015 Feb;36(2):538-48. doi: 10.1002/hbm.22645. Epub 2014 Oct 1.
5
Insular changes induced by electroconvulsive therapy response to symptom improvements in schizophrenia.电抽搐治疗对精神分裂症症状改善引起的岛叶变化。
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 8;89:254-262. doi: 10.1016/j.pnpbp.2018.09.009. Epub 2018 Sep 21.
6
Cortical and Subcortical Gray Matter Volume in Youths With Conduct Problems: A Meta-analysis.有行为问题的青少年的皮质和皮质下灰质体积：一项荟萃分析。
JAMA Psychiatry. 2016 Jan;73(1):64-72. doi: 10.1001/jamapsychiatry.2015.2423.
7
Group Cognitive Behavior Therapy Reversed Insula Subregions Functional Connectivity in Asthmatic Patients.团体认知行为疗法逆转了哮喘患者脑岛亚区的功能连接。
Front Aging Neurosci. 2017 Apr 18;9:105. doi: 10.3389/fnagi.2017.00105. eCollection 2017.
8
Brain structural alterations in MDD patients with gastrointestinal symptoms: Evidence from the REST-meta-MDD project.伴有胃肠道症状的 MDD 患者的大脑结构改变：来自 REST-meta-MDD 项目的证据。
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110386. doi: 10.1016/j.pnpbp.2021.110386. Epub 2021 Jun 11.
9
Aberrant Resting-State Functional Brain Connectivity of Insular Subregions in Obstructive Sleep Apnea.阻塞性睡眠呼吸暂停患者岛叶亚区域静息态功能脑连接异常
Front Neurosci. 2022 Jan 20;15:765775. doi: 10.3389/fnins.2021.765775. eCollection 2021.
10
Disrupted functional connectivity patterns of the insula subregions in drug-free major depressive disorder.药物治疗的抑郁症患者岛叶亚区功能连接模式紊乱。
J Affect Disord. 2018 Jul;234:297-304. doi: 10.1016/j.jad.2017.12.033. Epub 2017 Dec 28.

引用本文的文献

1
Real-time aggression in youth and its connection to region-specific structural brain alterations.青少年的实时攻击行为及其与特定区域脑结构改变的关联。
Discov Ment Health. 2025 Aug 18;5(1):124. doi: 10.1007/s44192-025-00273-8.
2
The Effect of Modular Degeneracy on Neuroimaging Data.模块化简并对神经影像数据的影响。
Brain Connect. 2025 Feb;15(1):19-29. doi: 10.1089/brain.2023.0090. Epub 2024 Dec 10.
3
Trauma, resilience and significant relationships: Sex differences in protective factors for military mental health.创伤、复原力与重要人际关系：军事心理健康保护因素中的性别差异

本文引用的文献

1
Morphometrical Brain Markers of Sex Difference.性别差异的脑形态学标志物
Cereb Cortex. 2021 Jul 5;31(8):3641-3649. doi: 10.1093/cercor/bhab037.
2
The role of lateralisation and sex on insular cortex: 3D volumetric analysis.侧化和性别的作用：岛叶皮层的 3D 容积分析。
Turk J Med Sci. 2021 Jun 28;51(3):1240-1248. doi: 10.3906/sag-2010-137.
3
Neural correlates of anger expression in patients with PTSD.创伤后应激障碍患者愤怒表达的神经相关性。
Aust N Z J Psychiatry. 2025 Jan;59(1):48-59. doi: 10.1177/00048674241286818. Epub 2024 Oct 11.
4
Neuroanatomical and neurocognitive correlates of delusion in Alzheimer's disease and mild cognitive impairment.阿尔茨海默病和轻度认知障碍中妄想的神经解剖学和神经认知相关性。
BMC Neurol. 2024 Mar 6;24(1):89. doi: 10.1186/s12883-024-03568-5.
Neuropsychopharmacology. 2021 Aug;46(9):1635-1642. doi: 10.1038/s41386-020-00942-y. Epub 2021 Jan 26.
4
Comparison of aggression in married men and women.已婚男女的攻击性比较。
J Pak Med Assoc. 2020 Oct;70(10):1723-1726. doi: 10.47391/JPMA.11193.
5
Recognizing Emotions through Facial Expressions: A Largescale Experimental Study.通过面部表情识别情绪：一项大规模实验研究。
Int J Environ Res Public Health. 2020 Oct 12;17(20):7420. doi: 10.3390/ijerph17207420.
6
The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects.人类攻击行为的神经生物学：神经影像学、遗传学和神经化学方面。
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 2;106:110059. doi: 10.1016/j.pnpbp.2020.110059. Epub 2020 Aug 19.
7
Oxytocin receptor gene polymorphism (rs53576) and digit ratio associates with aggression: comparison in seven ethnic groups.催产素受体基因多态性（rs53576）与数字比率与攻击行为相关：七个民族的比较。
J Physiol Anthropol. 2020 Aug 14;39(1):20. doi: 10.1186/s40101-020-00232-y.
8
Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior.攻击亚型与儿童和青少年破坏性行为的静息态功能连接有关。
Eur Child Adolesc Psychiatry. 2021 Aug;30(8):1237-1249. doi: 10.1007/s00787-020-01601-9. Epub 2020 Aug 13.
9
The impact of self-control training on neural responses following anger provocation.自我控制训练对愤怒激发后神经反应的影响。
Soc Neurosci. 2020 Oct;15(5):558-570. doi: 10.1080/17470919.2020.1799860. Epub 2020 Aug 5.
10
Dynamic Causal Modeling of Effective Connectivity During Anger Experience in Healthy Young Men: 7T Magnetic Resonance Imaging Study.健康青年男性愤怒体验期间有效连接性的动态因果模型：7T磁共振成像研究
Adv Cogn Psychol. 2019 Mar 13;15(1):52-62. doi: 10.5709/acp-0256-7. eCollection 2019.