Center of Cognitive Neurology, University of Paris, Lariboisière FW Hospital, APHP, Inserm 1184, Paris, France.
Memory Clinic, Paris, France.
Brain Behav. 2022 Apr;12(4):e2513. doi: 10.1002/brb3.2513. Epub 2022 Mar 15.
To assess FDG cerebral PET in patients suffering from cognitive impairment linked to Long COVID. The COVID pandemic has affected dozens of millions of people around the world and has resulted in the deaths of more than 3 million people. Following the acute forms, it has been reported sometimes long forms of COVID, with involvements of several organs including the brain. Neurological complications can include cognitive disturbances (brain fog) that are very common and can seriously disturb the life of patients.
Fluorodeoxyglucose PETs were performed in 3 patients with cognitive decline following COVID infection.
We report here 3 cases of brain fog with major hypometabolic areas of the pons revealed by the cerebral FDG PET.
The dysfunction of the locus coeruleus in these patients could partly explain the cognitive disorders observed. Further studies involving larger cohorts of patients suffering from cognitive dysfunction will be needed to determine if the brainstem is frequently affected in these patients.
评估 FDG 脑 PET 在与长新冠相关的认知障碍患者中的应用。新冠大流行已影响到全球数千万人，并导致 300 多万人死亡。在急性发病后，据报道有时会出现长期的新冠症状，涉及包括大脑在内的多个器官。神经并发症可包括认知障碍（脑雾），这种障碍非常常见，会严重干扰患者的生活。
对 3 例 COVID 感染后出现认知能力下降的患者进行氟脱氧葡萄糖 PET 检查。
我们在此报告 3 例脑雾病例，其大脑 FDG PET 显示脑桥出现主要低代谢区域。
这些患者蓝斑核功能障碍部分解释了所观察到的认知障碍。需要进一步研究更大的认知功能障碍患者队列，以确定这些患者的脑干是否经常受到影响。
