Filer Crist N
PerkinElmer Health Sciences, Inc., Waltham, Massachusetts, USA.
Cannabis Cannabinoid Res. 2023 Feb;8(1):1-4. doi: 10.1089/can.2021.0216. Epub 2022 Mar 15.
There appears to be consensus among biologists that delta-9-tetrahydrocannabinolic acid A (THCA-A) is the exclusive product of the enzyme THCA synthase. This then leaves an open question for formation of the THCA-A structural isomer, delta-9-tetrahydrocannabinolic acid B (THCA-B), discovered as a minor product in in 1969. With no reasonable biochemical pathway to explain the presence of THCA-B in , a synthetic route was next considered. Using established literature precedent, a photochemical mechanism has been proposed for the conversion of THCA-A to cannabidiolic acid (CBDA), followed by conversion of CBDA to THCA-B employing bond-breaking and bond-forming reactions.
生物学家们似乎已达成共识，即δ-9-四氢大麻酚酸A（THCA-A）是THCA合酶的唯一产物。这就留下了一个关于THCA-A结构异构体δ-9-四氢大麻酚酸B（THCA-B）形成的开放性问题，THCA-B于1969年被发现为次要产物。由于没有合理的生化途径来解释THCA-B的存在，接下来考虑了一条合成路线。根据已有的文献先例，有人提出了一种光化学机制，用于将THCA-A转化为大麻二酚酸（CBDA），然后通过断键和成键反应将CBDA转化为THCA-B。
