Howell W M, Black D A
Hum Genet. 1978 Jul 12;43(1):53-6. doi: 10.1007/BF00396478.
A simple and rapid technique is described whereby the nucleolus organizer regions (NORs) of human chromosomes can be differentially stained with silver. This staining is followed by trypsin-Giemsa banding on the same metaphase chromosomes. The metaphases simultaneously exhibit silver-stained NORs and G bands, allowing for the unequivocal identification of all chromosomes and greatly facilitating studies involving the NOR-bearing acrocentrics.
本文描述了一种简单快速的技术，通过该技术可对人类染色体的核仁组织区（NORs）进行银染差异染色。在同一中期染色体上进行这种染色后，再进行胰蛋白酶 - 吉姆萨显带。中期染色体同时显示银染的NORs和G带，从而能够明确识别所有染色体，并极大地促进了涉及携带NOR的近端着丝粒染色体的研究。
