Zeiger E, Tennant R W
Prog Clin Biol Res. 1986;209B:75-84.
The expectations of the ability of in vitro mutagenesis and clastogenesis assays to unambiguously detect chemical carcinogens have not been fulfilled. The results of this study show a constant error rate in the identification of noncarcinogens with mutagenic potential. Also, different chemical carcinogen classes showed different correlations with mutagenicity. The relationship is further complicated by differential patterns of tumor induction in rodents. Therefore, while in vitro mutagenicity and clastogenicity define important properties of chemicals, additional information is required in order to clearly relate such results to potential carcinogenicity.
体外诱变和染色体断裂分析明确检测化学致癌物能力的期望尚未实现。本研究结果表明，在鉴定具有诱变潜力的非致癌物时存在恒定的错误率。此外，不同类别的化学致癌物与诱变性表现出不同的相关性。啮齿动物中肿瘤诱导的差异模式使这种关系更加复杂。因此，虽然体外诱变性和染色体断裂性定义了化学物质的重要特性，但为了将这些结果与潜在致癌性明确关联起来，还需要额外的信息。
