Cibikkarthik T, Smiline Girija A S, Vijayashree Priyadharsini J
Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.
Bioinformation. 2021 Dec 31;17(12):1105-1108. doi: 10.6026/973206300171105. eCollection 2021.
The development of antimicrobial drug resistance has encouraged scientists to develop alternate methods to combat infectious pathogens associated with dental diseases. Therefore, it is of interest to predict interactions for catechin (a plant derived compound) with protein targets in the red complex pathogens using computer aided network tools. However, in vitro and in vivo studies are warranted to confirm the antimicrobial effect of catechin (gallocatechin, epicatechin, epigallactocatechin (EGC) and gallolyl catechins) on the dental pathogens.
抗菌药物耐药性的发展促使科学家们开发替代方法来对抗与牙科疾病相关的传染性病原体。因此,利用计算机辅助网络工具预测儿茶素(一种植物衍生化合物)与红色复合体病原体中蛋白质靶点的相互作用具有重要意义。然而,需要进行体外和体内研究来证实儿茶素(没食子儿茶素、表儿茶素、表没食子儿茶素(EGC)和没食子酰儿茶素)对牙科病原体的抗菌作用。