表儿茶素水合物增强选定抗生素对金黄色葡萄球菌临床菌株的抗菌作用。
Catechin Hydrate Augments the Antibacterial Action of Selected Antibiotics against Staphylococcus aureus Clinical Strains.
作者信息
Miklasińska Maria, Kępa Małgorzata, Wojtyczka Robert D, Idzik Danuta, Dziedzic Arkadiusz, Wąsik Tomasz J
机构信息
Department of Microbiology and Virology, School of Pharmacy and Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, ul. Jagiellońska 4, 41-200 Sosnowiec, Poland.
Department of Conservative Dentistry with Endodontics, Medical University of Silesia, Katowice, Pl. Akademicki 17, 41-902 Bytom, Poland.
出版信息
Molecules. 2016 Feb 20;21(2):244. doi: 10.3390/molecules21020244.
Abstract
Synergistic effects between commonly used antibiotics and natural substances may be an alternative to conventional antibacterial therapies. The objective of the presented study was to assess the in vitro antibacterial activity of catechin hydrate (CH) and evaluate the interactions of CH with selected antibiotics using Staphylococcus aureus clinical and reference strains. CH displayed diverse activity towards examined S. aureus strains, with minimal inhibitory concentrations (MICs) ranging from 256 to 2048 µg/mL. The interaction between CH and antibiotics was assessed by an E-test. The most significant synergistic effects were noticed for CH in combination with clindamycin and erythromycin. For cefoxitin and vancomycin a decrease of MIC values in the presence of CH was also observed, but it did not reach statistical significance. The obtained results demonstrate that CH shows antimicrobial activity against Staphylococcus aureus clinical strains. What is more, we proved a synergistic effect of CH with erythromycin and clindamycin.
摘要
常用抗生素与天然物质之间的协同效应可能是传统抗菌疗法的一种替代方案。本研究的目的是评估儿茶素水合物（CH）的体外抗菌活性，并使用金黄色葡萄球菌临床菌株和参考菌株评估CH与选定抗生素之间的相互作用。CH对所检测的金黄色葡萄球菌菌株表现出不同的活性，最低抑菌浓度（MIC）范围为256至2048µg/mL。通过E试验评估CH与抗生素之间的相互作用。CH与克林霉素和红霉素联合使用时观察到最显著的协同效应。对于头孢西丁和万古霉素，在CH存在的情况下也观察到MIC值降低，但未达到统计学显著性。所得结果表明，CH对金黄色葡萄球菌临床菌株具有抗菌活性。此外，我们证明了CH与红霉素和克林霉素具有协同效应。
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