Thariny E, Smiline Girija A M, Paramasivam A, Vijayashree Priyadharsini J
Bioinformation. 2021 Dec 31;17(12):113-119. doi: 10.6026/973206300171113. eCollection 2021.
Head and neck cancer is a debilitating disease with several etiological factors. One of the main etiologies to be noticed is the alteration, which is either caused by genetic or environmental factors. Therefore, it is of interest to assess the effect of genetic alterations, especially the non-synonymous mutations of the SMAD gene family and its possible association with HNSCC. Data shows a significant novel mutation in the SMAD gene family in association with head and neck squamous cell carcinoma (HNSCC), which would aid in better diagnosis and treatment planning for cancer.
头颈癌是一种由多种病因引起的使人衰弱的疾病。需要注意的主要病因之一是改变，这种改变是由遗传或环境因素引起的。因此，评估基因改变的影响，尤其是SMAD基因家族的非同义突变及其与头颈部鳞状细胞癌（HNSCC）的可能关联，是很有意义的。数据显示，SMAD基因家族存在与头颈部鳞状细胞癌相关的显著新突变，这将有助于对头颈癌进行更好的诊断和治疗规划。
