Liu Wenli, Rodgers Griffin P
Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Open Forum Infect Dis. 2022 Feb 8;9(4):ofac061. doi: 10.1093/ofid/ofac061. eCollection 2022 Apr.
Biomarkers of infectious diseases are essential tools for patient monitoring, diagnostics, and prognostics. Here we review recent advances in our understanding of olfactomedin 4 (OLFM4) in neutrophil biology and of OLFM4 as a new biomarker for certain infectious diseases. OLFM4 is a neutrophil-specific granule protein that is expressed in a subset of human and mouse neutrophils. OLFM4 expression is upregulated in many viral and bacterial infections, as well as in malaria. OLFM4 appears to play an important role in regulating host innate immunity against bacterial infection. Further, higher expression of OLFM4 is associated with severity of disease for dengue virus, respiratory syncytial virus, and malaria infections. In addition, higher expression of OLFM4 or a higher percentage of OLFM4 + neutrophils is associated with poorer outcomes in septic patients. OLFM4 is a promising biomarker and potential therapeutic target in certain infectious diseases.
传染病生物标志物是用于患者监测、诊断和预后评估的重要工具。在此，我们综述了近期在对嗅觉介素4（OLFM4）在中性粒细胞生物学中的认识以及OLFM4作为某些传染病新生物标志物方面取得的进展。OLFM4是一种中性粒细胞特异性颗粒蛋白，在人和小鼠的一部分中性粒细胞中表达。在许多病毒和细菌感染以及疟疾中，OLFM4的表达会上调。OLFM4似乎在调节宿主针对细菌感染的固有免疫中发挥重要作用。此外，OLFM4的高表达与登革热病毒、呼吸道合胞病毒和疟疾感染的疾病严重程度相关。此外，OLFM4的高表达或OLFM4+中性粒细胞的高比例与脓毒症患者较差的预后相关。OLFM4是某些传染病中有前景的生物标志物和潜在治疗靶点。
