Okunoye Olaitan, Marston Louise, Walters Kate, Schrag Anette
Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Department of Primary Care and Population Health, University College London, London, UK.
NPJ Parkinsons Dis. 2022 Mar 15;8(1):23. doi: 10.1038/s41531-022-00284-0.
Parkinson's disease (PD) has the fastest rising prevalence of all neurodegenerative diseases worldwide. However, it is unclear whether its incidence has increased after accounting for age and changes in diagnostic patterns in the same population. We conducted a cohort study in individuals aged ≥50 years within a large UK primary care database between January 2006 and December 2016. To account for possible changes in diagnostic patterns, we calculated the incidence of PD using four case definitions with different stringency derived from the combination of PD diagnosis, symptoms, and treatment. Using the broadest case definition, the incidence rate (IR) per 100,000 person years at risk (PYAR) was 149 (95% CI 143.3-155.4) in 2006 and 144 (95% CI 136.9-150.7) in 2016. In conclusion, the incidence of PD in the UK remained stable between 2006 and 2016, when accounting for age and diagnostic patterns, suggesting no major change in underlying risk factors for PD during this time period in the UK.
帕金森病（PD）在全球所有神经退行性疾病中患病率上升速度最快。然而，在考虑年龄和同一人群诊断模式变化后，其发病率是否有所增加尚不清楚。我们于2006年1月至2016年12月期间，在英国一个大型基层医疗数据库中对年龄≥50岁的个体进行了一项队列研究。为了考虑诊断模式可能的变化，我们使用从帕金森病诊断、症状和治疗组合中得出的四种不同严格程度的病例定义来计算帕金森病的发病率。使用最宽泛的病例定义，2006年每10万人年风险（PYAR）的发病率（IR）为149（95%CI 143.3 - 155.4），2016年为144（95%CI 136.9 - 150.7）。总之，在考虑年龄和诊断模式后，英国帕金森病的发病率在2006年至2016年期间保持稳定，这表明在此期间英国帕金森病的潜在风险因素没有重大变化。
