Department of Otolaryngology, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey.
Department of Pathology, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey.
Acta Otorhinolaryngol Ital. 2022 Feb;42(1):34-40. doi: 10.14639/0392-100X-N1034.
chromosomal rearrangement is frequently seen in thyroid cancer, and overexpression has been shown in the follicular variant of papillary thyroid carcinoma, but not in papillary thyroid carcinoma other than the follicular variant. The main aim of this study was to investigate the frequency of overexpression among papillary thyroid carcinoma and if there were any variants of papillary thyroid carcinoma with overexpression other than the follicular variant.
Immunohistochemical analysis of overexpression was performed using a monoclonal antibody in a series of 111 paraffin-embedded blocks of thyroid tumours. Of the patients in our study, 100 were diagnosed with papillary thyroid carcinoma, 9 with follicular adenoma and 2 with follicular carcinoma.
staining was detected in 19 of the 111 cases. Sixteen patients with overexpression had papillary thyroid carcinoma and 3 had follicular adenoma.
overexpression was detected mainly in follicular-variant papillary thyroid carcinoma. Vascular invasion, lymphatic invasion, thyroid capsule invasion and lymph node positivity were lower in patients with overexpression.
染色体重排在甲状腺癌中很常见，在滤泡型甲状腺乳头状癌中已显示过表达，但在滤泡型以外的甲状腺乳头状癌中没有。本研究的主要目的是调查甲状腺乳头状癌中 过表达的频率，以及除滤泡型以外是否存在其他具有 过表达的甲状腺乳头状癌变体。
使用针对 的单克隆抗体对 111 例甲状腺肿瘤石蜡包埋块进行免疫组织化学分析。在我们的研究中，100 例患者被诊断为甲状腺乳头状癌，9 例为滤泡性腺瘤，2 例为滤泡癌。
在 111 例中检测到染色 19 例。在 过表达的 16 例患者中，有 16 例患有甲状腺乳头状癌，3 例患有滤泡性腺瘤。
过表达主要在滤泡型甲状腺乳头状癌中检测到。在 过表达的患者中，血管侵犯、淋巴侵犯、甲状腺包膜侵犯和淋巴结阳性率较低。
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