血清叶黄素是老年 2 型糖尿病和糖尿病肾病有前途的生物标志物。
Serum lutein is a promising biomarker for type 2 diabetes mellitus and diabetic kidney disease in the elderly.
机构信息
Department of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
出版信息
J Clin Lab Anal. 2022 Apr;36(4):e24350. doi: 10.1002/jcla.24350. Epub 2022 Mar 15.
OBJECTIVE
To investigate the relationship between serum lutein and type 2 diabetes mellitus (T2DM) and diabetic kidney disease (DKD) in elderly individuals.
METHODS
A total of 60 T2DM patients over 60 years were subgrouped into a DKD group and a non-DKD group according to their urinary microalbumin-to-creatinine ratio (UACR), while 30 age-matched non-T2DM patients were recruited in the control group. Baseline characteristics, laboratory examination results, and serum lutein levels were compared, and their correlations were analyzed. Receiver operating characteristic (ROC) curves were plotted to identify the diagnostic potential of lutein in T2DM and DKD.
RESULTS
The lutein level in the T2DM group was significantly lower than that in the control group and was also significantly lower in the DKD group than in the non-DKD group (p < 0.001). Lutein levels were negatively correlated with body mass index, glycosylated hemoglobin, fasting blood glucose, triglyceride, and UACR and positively correlated with high-density lipoprotein cholesterol (p < 0.05). T2DM patients were divided into four groups according to the quartile of their lutein level. The proportion of T2DM and DKD gradually decreased with increasing lutein levels (p < 0.001). The area under the ROC curve of serum lutein in diagnosing T2DM and DKD was 0.880 and 0.779, respectively, with corresponding cut-off values of 0.433 μmol/L and 0.197 μmol/L (p < 0.001).
CONCLUSION
The serum level of lutein is negatively correlated with the incidence of T2DM and DKD in the elderly and can serve as a diagnostic marker for T2DM and DKD.
目的
探讨血清中叶黄素与老年 2 型糖尿病（T2DM）及糖尿病肾病（DKD）的关系。
方法
根据尿微量白蛋白与肌酐比值（UACR），将 60 例 60 岁以上的 T2DM 患者分为 DKD 组和非 DKD 组，另选取 30 例年龄匹配的非 T2DM 患者为对照组。比较各组的一般资料、实验室检查结果和血清中叶黄素水平，并分析其相关性。绘制受试者工作特征（ROC）曲线，以确定叶黄素对 T2DM 和 DKD 的诊断价值。
结果
T2DM 组的叶黄素水平明显低于对照组，且 DKD 组明显低于非 DKD 组（p<0.001）。叶黄素水平与体重指数、糖化血红蛋白、空腹血糖、甘油三酯和 UACR 呈负相关，与高密度脂蛋白胆固醇呈正相关（p<0.05）。根据叶黄素四分位数将 T2DM 患者分为 4 组，随着叶黄素水平的升高，T2DM 和 DKD 的比例逐渐降低（p<0.001）。血清叶黄素诊断 T2DM 和 DKD 的 ROC 曲线下面积分别为 0.880 和 0.779，对应的截断值分别为 0.433μmol/L 和 0.197μmol/L（p<0.001）。
结论
血清中叶黄素水平与老年 T2DM 和 DKD 的发生率呈负相关，可作为 T2DM 和 DKD 的诊断标志物。
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