Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari Medical School, Bari, Italy.
Clin Anat. 2022 May;35(4):537-541. doi: 10.1002/ca.23852. Epub 2022 Mar 25.
In 1986, Rita Levi-Montalcini and Stanley Cohen were awarded with the Nobel Prize for Physiology and Medicine for the discovery of the nerve growth factor. Among the experimental models used by Levi-Montalcini in the first part of her studies it was the chick embryo chorioallantoic membrane, currently used in the study of tumor growth and angiogenesis. Levi-Montalcini grafted fragments of mouse sarcomas on to the chorioallantoic membranes of 4- to 6-day chick embryos and demonstrated that the tumors infiltrated the host blood vessels. Moreover, the ganglia showed hypertrophy, nerve fibers reaching to the implanted tumors. Levi-Montalcini hypothesized that the effects could have been mediated by a soluble factor, which was later identified as the nerve growth factor.
1986 年，丽塔·列维-蒙塔尔奇尼和斯坦利·科恩因发现神经生长因子而获得诺贝尔生理学或医学奖。在列维-蒙塔尔奇尼研究的第一部分中，她使用了鸡胚绒毛尿囊膜作为实验模型，该模型目前用于研究肿瘤生长和血管生成。列维-蒙塔尔奇尼将小鼠肉瘤的片段移植到 4 至 6 天大的鸡胚绒毛尿囊膜上，并证明肿瘤浸润了宿主血管。此外，神经节显示出肥大，神经纤维延伸到植入的肿瘤。列维-蒙塔尔奇尼假设这些作用可能是由一种可溶性因子介导的，后来该因子被确定为神经生长因子。
