[体外容积扩张辅助自体脂肪移植乳房重建的研究进展]
[Research progress of external volume expansion assisted autologous fat grafting for breast reconstruction].
作者信息
Ma Xuan, Li Facheng
机构信息
The 18th Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100144, P. R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2022 Mar 15;36(3):370-375. doi: 10.7507/1002-1892.202111016.
OBJECTIVE
To review the application progress, mechanism, application points, limitations, and oncological safety of external volume expansion (EVE) assisted autologous fat grafting for breast reconstruction and provide a reference for optimizing the design of EVE.
METHODS
Based on the latest relevant articles, the basic experiments and clinical applications of EVE were summarized.
RESULTS
EVE can reduce interstitial fluid pressure, increase blood supply, and promote adipogenic differentiation, thereby benefiting the survival of transplanted fat. EVE assisted autologous fat grafting in clinical practice can improve the retention rate of breast volume and the outcome of breast reconstruction, meanwhile it doesn't increase the risk of local recurrence. But there is no standard parameters for application, and there are many complications and limitations.
CONCLUSION
EVE improves the survival of transplanted fat, but its complications and poor compliance are obvious, so it is urgent to further investigate customized products for breast reconstruction after breast cancer and establish relevant application guidelines.
目的
综述体外容积扩张（EVE）辅助自体脂肪移植用于乳房重建的应用进展、机制、应用要点、局限性及肿瘤学安全性，为优化EVE设计提供参考。
方法
基于最新相关文章，总结EVE的基础实验及临床应用情况。
结果
EVE可降低组织间液压力，增加血供，促进脂肪生成分化，从而有利于移植脂肪存活。EVE辅助自体脂肪移植在临床实践中可提高乳房容积保留率及乳房重建效果，同时不增加局部复发风险。但应用尚无标准参数，且存在诸多并发症及局限性。
结论
EVE提高了移植脂肪的存活率，但其并发症及依从性差的问题较为明显，因此迫切需要进一步研究针对乳腺癌术后乳房重建的定制产品并制定相关应用指南。
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