Zfp1，一种 Cys2His2 锌指蛋白，在. 的减数分裂起始中是必需的。
Zfp1, a Cys2His2 zinc finger protein is required for meiosis initiation in .
机构信息
Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, China.
Department of Chromosome Biology and Max F. Perutz Laboratories, Center for Molecular Biology, University of Vienna, Vienna, Austria.
出版信息
Cell Cycle. 2022 Jul;21(13):1422-1433. doi: 10.1080/15384101.2022.2053449. Epub 2022 Mar 16.
Meiosis is an important and highly conserved process that occurs during eukaryotic sexual reproduction. Diverse mechanisms are responsible for meiosis initiation among eukaryotes, and transcription factors have been established to have an important role in many species. However, the specific function of transcription factors in initiating meiosis in ciliates is unknown. Here we show that a putative Cys2His2 zinc finger-containing transcription factor encoded by the gene is specifically expressed during sexual reproduction in . Meiosis is not initiated in the cells lacking . Transcriptome sequencing analyses reveal that Zfp1 is required for the expression of many meiosis-specific genes. Our results indicate that Zfp1 could be a transcriptional activator required for meiosis initiation in .
减数分裂是真核生物有性生殖过程中发生的一个重要且高度保守的过程。不同的机制负责真核生物减数分裂的起始，转录因子已被确定在许多物种中具有重要作用。然而，转录因子在纤毛虫中启动减数分裂的具体功能尚不清楚。在这里，我们显示出由 基因编码的一种假定的含 Cys2His2 锌指的转录因子在 的有性生殖过程中特异性表达。在缺乏 的细胞中，减数分裂不会起始。转录组测序分析表明，Zfp1 是许多减数分裂特异性基因表达所必需的。我们的结果表明，Zfp1 可能是启动 减数分裂起始所必需的转录激活因子。
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