Wang Meiyu, Gao Bin, Wang Xiaoyu, Li Wenzhong, Feng Yakai
School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, China.
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.
Biomater Sci. 2022 Apr 12;10(8):1883-1903. doi: 10.1039/d2bm00067a.
Stimulus-responsive materials have been widely studied and applied in biomedical fields. Under the stimulation of enzymes, enzyme-responsive materials (ERMs) can be triggered to change their structures, properties and functions. Herein, natural enzymes act as the endogenous trigger. Owing to the specificity of natural enzymes, ERMs can exert functions in the specific tissues containing these enzymes, while remaining inert in other tissues. This is beneficial for modulating the therapy efficacy and alleviating systemic or local toxicities when ERMs are used to deliver therapeutic molecules. This article focuses on introducing enzyme-responsive strategies, ERMs and their applications in cancer and cardiovascular disease diagnosis, therapy and theranostics. Enzyme-responsive strategies provide a promising research cue to construct intelligent biomaterials for disease treatment and diagnosis.
刺激响应材料已在生物医学领域得到广泛研究和应用。在酶的刺激下，酶响应材料（ERM）可被触发改变其结构、性质和功能。在此，天然酶作为内源性触发因素。由于天然酶的特异性，ERM可在含有这些酶的特定组织中发挥作用，而在其他组织中保持惰性。当ERM用于递送治疗分子时，这有利于调节治疗效果并减轻全身或局部毒性。本文重点介绍酶响应策略、ERM及其在癌症和心血管疾病诊断、治疗及诊疗中的应用。酶响应策略为构建用于疾病治疗和诊断的智能生物材料提供了一个有前景的研究线索。
